onr:"swepub:oai:DiVA.org:ri-26586"
Sökning: onr:"swepub:oai:DiVA.org:ri-26586" > Micellization and g...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02459naa a2200265 4500 | |
| 001 | oai:DiVA.org:ri-26586 | |
| 003 | SwePub | |
| 008 | 161208s2000 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-265862 URI |
| 040 | a (SwePub)ri | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Scherlund, M4 aut |
| 245 | 1 0 | a Micellization and gelation in block copolymer systems containing local anesthetics |
| 264 | 1 | c 2000 |
| 338 | a print2 rdacarrier | |
| 500 | a A1393 | |
| 520 | a A formulation consisting of a eutectic mixture of lidocaine and prilocaine, Lutrol(R) F68 and Lutrol(R) F127, suitable for anesthetizing the periodontal pocket has previously been developed. This consists of discrete micelles with a diameter of 20-30 nm and has a suitable gelation temperature, a good release profile and excellent long-term stability. In this study, the unimer/micelle transition and gel formation of the formulation, in its concentrated state, are investigated using differential scanning calorimetry (DSC), dye solubilization, rheology, and nuclear magnetic resonance (NMR) self-diffusion. The critical micellization temperature (cmt) and gelation temperature are found to be interconnected and influenced by cosolutes, such as electrolytes and hydrophobic substances, the latter as found particularly for the eutectic mixture of the local anesthetic agents lidocaine and prilocaine. Both cmt and the gelation temperature decrease with increasing pH of the system, i.e. at reduced solubility of the active ingredients. Moreover, both cmt and the gelation temperature increase upon diluting the system with water. The ratio between the two block copolymers present in the system also has an impact on both cmt and the gelation temperature, resulting in a decrease in onset tt temperature of both processes with an increase of Lutrol(R) F127, The amount of the active ingredients present in the micelle phase depends on the pH of thc system bring approximately 0% w/w at pH 5, 50-60% w/w at pH 7.8 and 80% w/w at pH 9. | |
| 700 | 1 | a Brodin, A4 aut |
| 700 | 1 | a Malmsten, Mu RISE,YKI – Ytkemiska institutet4 aut |
| 710 | 2 | a RISEb YKI – Ytkemiska institutet4 org |
| 773 | 0 | t International Journal of Pharmaceuticsg 211, s. 37-49q 211<37-49x 0378-5173x 1873-3476 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-26586 |
Hitta via bibliotek
- International Journal of Pharmaceutics (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Scherlund, M
- Brodin, A
- Malmsten, M
- Artiklar i publikationen
- International Jo ...
- Av lärosätet
- RISE
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
