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Protein-polyelectro...
Protein-polyelectrolyte cluster formation and redissolution: A Monte Carlo study
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Carlsson, F (författare)
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- Malmsten, Martin (författare)
- Uppsala universitet,RISE,YKI – Ytkemiska institutet,Institutionen för farmaci
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- Linse, Per (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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(creator_code:org_t)
- American Chemical Society (ACS), 2003
- 2003
- Engelska.
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Ingår i: Journal of The American Ceramic Society. - : American Chemical Society (ACS). - 0002-7820 .- 1551-2916. ; 125:10, s. 3140-9
- Relaterad länk:
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http://www.ncbi.nlm....
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visa fler...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aqueous solutions of proteins and oppositely charged polyelectrolytes were studied at different polyelectrolyte chain length, ionic strength, and protein-protein interaction potential as a function of the polyelectrolyte concentration. One of the protein models used represented lysozyme in aqueous environment. The model systems were solved by Monte Carlo simulations, and their properties were analyzed in terms of radial distribution functions, structure factors, and cluster composition probabilities. In the system with the strongest electrostatic protein-polyelectrolyte interaction the largest clusters were formed near or at equivalent amount of net protein charge and polyelectrolyte charge, whereas in excess of polyelectrolyte a redissolution appeared. Shorter polyelectrolyte chains and increased ionic strength lead to weaker cluster formation. An inclusion of nonelectrostatic protein-protein attraction promoted the protein-polyelectrolyte cluster formation.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- LINEAR CHARGE-DENSITY
- CATIONIC POLYELECTROLYTES
- BRIDGING FLOCCULATION
- MACROION COMPLEXATION
- CHAIN FLEXIBILITY
- SIMULATIONS
- LYSOZYME
- MICELLES
- ADSORPTION
- PARTICLES
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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