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Highly Customizable...
Highly Customizable Bone Fracture Fixation through the Marriage of Composites and Screws
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- Hutchinson, Daniel (författare)
- KTH,Ytbehandlingsteknik,KTH Royal Institute of Technology, Sweden
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- Granskog, Viktor (författare)
- KTH,Fiber- och polymerteknologi,KTH Royal Institute of Technology, Sweden
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- von Kieseritzky, Johanna (författare)
- Karolinska Institutet
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- Alfort, Henrik (författare)
- Karolinska Institutet
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- Stenlund, Patrik (författare)
- RISE,Kemi, biomaterial och textil
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- Zhang, Yuning (författare)
- KTH,Fiber- och polymerteknologi,KTH Royal Institute of Technology, Sweden
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- Arner, Marianne (författare)
- Karolinska Institutet
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- Håkansson, Joakim (författare)
- Gothenburg University,Göteborgs universitet,RISE,Kemi, biomaterial och textil,University of Gothenburg, Sweden,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Malkoch, Michael, 1974- (författare)
- KTH,Ytbehandlingsteknik,KTH Royal Institute of Technology, Sweden
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(creator_code:org_t)
- 2021-06-18
- 2021
- Engelska.
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Ingår i: Advanced Functional Materials. - : John Wiley and Sons Inc. - 1616-301X .- 1616-3028. ; 31:41
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Open reduction internal fixation (ORIF) metal plates provide exceptional support for unstable bone fractures; however, they often result in debilitating soft-tissue adhesions and their rigid shape cannot be easily customized by surgeons. In this work, a surgically feasible ORIF methodology, called AdhFix, is developed by combining screws with polymer/hydroxyapatite composites, which are applied and shaped in situ before being rapidly cured on demand via high-energy visible-light-induced thiol–ene coupling chemistry. The method is developed on porcine metacarpals with transverse and multifragmented fractures, resulting in strong and stable fixations with a bending rigidity of 0.28 (0.03) N m2 and a maximum load before break of 220 (15) N. Evaluations on human cadaver hands with proximal phalanx fractures show that AdhFix withstands the forces from finger flexing exercises, while short- and long-term in vivo rat femur fracture models show that AdhFix successfully supports bone healing without degradation, adverse effects, or soft-tissue adhesions. This procedure represents a radical new approach to fracture fixation, which grants surgeons unparalleled customizability and does not result in soft-tissue adhesions. © 2021 The Authors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- biomaterials
- bone fixation
- materials engineering
- thiol–ene composites
- Adhesion
- Bone
- Fracture fixation
- Screws
- Tissue
- Adverse effect
- Bending rigidity
- Bone-fracture fixation
- Coupling chemistry
- Customizability
- Internal fixation
- New approaches
- Visible light induced
- Fracture
- biomaterials
- bone fixation
- materials engineering
- thiol-ene composites
- plate fixation
- complications
- epidemiology
- injuries
- hand
- Chemistry
- Science & Technology - Other Topics
- Materials Science
- Physics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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