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Personalized tissue...
Personalized tissue-engineered arteries as vascular graft transplants : A safety study in sheep
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- Jenndahl, L. (författare)
- VERIGRAFT AB, Sweden
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- Österberg, Klas, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Bogestål, Yalda (författare)
- RISE,Metodik för produktframtagning
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visa fler...
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- Simsa, R. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Gustafsson-Hedberg, T. (författare)
- VERIGRAFT AB, Sweden
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- Stenlund, Patrik (författare)
- RISE,Metodik för produktframtagning
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- Petronis, Sarunas (författare)
- RISE,Metodik för produktframtagning
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- Krona, Annika (författare)
- RISE,Jordbruk och livsmedel
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- Fogelstrand, Per, 1971 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Strehl, R. (författare)
- VERIGRAFT AB, Sweden
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- Håkansson, Joakim (författare)
- Gothenburg University,Göteborgs universitet,RISE,Metodik för produktframtagning,University of Gothenburg, Sweden,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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(creator_code:org_t)
- Japanese Society of Regenerative Medicine, 2022
- 2022
- Engelska.
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Ingår i: Regenerative Therapy. - : Japanese Society of Regenerative Medicine. - 2352-3204. ; 21, s. 331-341
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Patients with cardiovascular disease often need replacement or bypass of a diseased blood vessel. With disadvantages of both autologous blood vessels and synthetic grafts, tissue engineering is emerging as a promising alternative of advanced therapy medicinal products for individualized blood vessels. By reconditioning of a decellularized blood vessel with the recipient's own peripheral blood, we have been able to prevent rejection without using immunosuppressants and prime grafts for efficient recellularization in vivo. Recently, decellularized veins reconditioned with autologous peripheral blood were shown to be safe and functional in a porcine in vivo study as a potential alternative for vein grafting. In this study, personalized tissue engineered arteries (P-TEA) were developed using the same methodology and evaluated for safety in a sheep in vivo model of carotid artery transplantation. Five personalized arteries were transplanted to carotid arteries and analyzed for safety and patency as well as with histology after four months in vivo. All grafts were fully patent without any occlusion or stenosis. The tissue was well cellularized with a continuous endothelial cell layer covering the luminal surface, revascularized adventitia with capillaries and no sign of rejection or infection. In summary, the results indicate that P-TEA is safe to use and has potential as clinical grafts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- ATMP
- Blood vessels
- Recellularization
- Regenerative medicine
- Scaffold
- Tissue engineering
- amoxicillin
- attane
- buprenorphine
- carprofen
- clopidogrel
- dalteparin
- dexmedetomidine
- heparin
- isoflurane
- norocarp
- poliglecaprone
- promea
- propofol
- receptor type tyrosine protein phosphatase C
- vetergesic
- vetrimoxin
- adventitia
- anatomical concepts
- angiography
- animal experiment
- animal model
- animal tissue
- antibiotic prophylaxis
- arterial stiffness
- artery anastomosis
- artery transplantation
- Article
- biomechanics
- biopsy technique
- blood flow
- blood vessel graft
- blood vessel parameters
- blood vessel wall
- burst pressure
- capillary
- carotid artery transplantation
- confocal laser scanning microscopy
- controlled study
- decellularization
- decellularized blood vessel
- device safety
- DNA extraction
- end to end anastomosis
- endothelial cell layer
- evening dosage
- extracellular matrix
- failure strain
- female
- fluorescence microscopy
- full luminal endothelialization
- histology
- hyperplasia
- immunohistochemistry
- intimal hyperplasia
- luminal surface
- medical procedures
- morning dosage
- nonhuman
- reconditioning of vascular graft
- revascularization
- scanning electron microscopy
- ATMP
- Blood vessels
- Recellularization
- Regenerative medicine
- Scaffold
- Tissue engineering
- amoxicillin
- attane
- buprenorphine
- carprofen
- clopidogrel
- dalteparin
- dexmedetomidine
- heparin
- isoflurane
- norocarp
- poliglecaprone
- promea
- propofol
- receptor type tyrosine protein phosphatase C
- vetergesic
- vetrimoxin
- adventitia
- anatomical concepts
- angiography
- animal experiment
- animal model
- animal tissue
- antibiotic prophylaxis
- arterial stiffness
- artery anastomosis
- artery transplantation
- Article
- biomechanics
- biopsy technique
- blood flow
- blood vessel graft
- blood vessel parameters
- blood vessel wall
- burst pressure
- capillary
- carotid artery transplantation
- confocal laser scanning microscopy
- controlled study
- decellularization
- decellularized blood vessel
- device safety
- DNA extraction
- end to end anastomosis
- endothelial cell layer
- evening dosage
- extracellular matrix
- failure strain
- female
- fluorescence microscopy
- full luminal endothelialization
- histology
- hyperplasia
- immunohistochemistry
- intimal hyperplasia
- luminal surface
- medical procedures
- morning dosage
- nonhuman
- reconditioning of vascular graft
- revascularization
- scanning electron microscopy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Jenndahl, L.
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Österberg, Klas, ...
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Bogestål, Yalda
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Simsa, R.
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Gustafsson-Hedbe ...
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Stenlund, Patrik
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visa fler...
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Petronis, Saruna ...
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Krona, Annika
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Fogelstrand, Per ...
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Strehl, R.
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Håkansson, Joaki ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Regenerative The ...
- Av lärosätet
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RISE
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Göteborgs universitet