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Cross-sectional str...
Cross-sectional structure evolution of phase-separated spin-coated ethylcellulose/hydroxypropylcellulose films during solvent quenching
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- Carmona, Pierre, 1995 (författare)
- RISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden,Chalmers tekniska högskola
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- von Corswant, Christian (författare)
- AstraZeneca, Sweden,AstraZeneca AB
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- Röding, Magnus (författare)
- Gothenburg University,RISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden; Gothenburg University, Sweden,Göteborgs universitet,University of Gothenburg,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences
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- Särkkä, Aila, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers University of Technology, Sweden; Gothenburg University, Sweden
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- Olsson, Eva, 1960 (författare)
- Chalmers University of Technology, Sweden,Chalmers tekniska högskola
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- Loren, Niklas (författare)
- RISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden,Chalmers tekniska högskola
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(creator_code:org_t)
- 2022
- 2022
- Engelska.
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Ingår i: RSC Advances. - : Royal Society of Chemistry. - 2046-2069. ; 12:40, s. 26078-26089
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Porous phase-separated ethylcellulose/hydroxypropylcellulose (EC/HPC) films are used to control drug transport out of pharmaceutical pellets. The films are applied on the pellets using fluidized bed spraying. The drug transport rate is determined by the structure of the porous films that are formed as the water-soluble HPC leaches out. However, a detailed understanding of the evolution of the phase-separated structure during production is lacking. Here, we have investigated EC/HPC films produced by spin-coating, which mimics the industrial manufacturing process. This work aimed to understand the structure formation and film shrinkage during solvent evaporation. The cross-sectional structure evolution was characterized using confocal laser scanning microscopy (CLSM), profilometry and image analysis. The effect of the EC/HPC ratio on the cross-sectional structure evolution was investigated. During shrinkage of the film, the phase-separated structure undergoes a transition from 3D to nearly 2D structure evolution along the surface. This transition appears when the typical length scale of the phase-separated structure is on the order of the thickness of the film. This was particularly pronounced for the bicontinuous systems. The shrinkage rate was found to be independent of the EC/HPC ratio, while the initial and final film thickness increased with increasing HPC fraction. A new method to estimate part of the binodal curve in the ternary phase diagram for EC/HPC in ethanol has been developed. The findings of this work provide a good understanding of the mechanisms responsible for the morphology development and allow tailoring of thin EC/HPC films structure for controlled drug release.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi -- Oorganisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Inorganic Chemistry (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Nyckelord
- Controlled drug delivery
- Morphology
- Pelletizing
- Separation
- Shrinkage
- Cross-sectional structures
- Drug transport
- Drug transport rates
- Ethylcellulose
- Hydroxypro-pylcellulose
- Industrial manufacturing process
- Phase-separated structures
- Porous film
- Structure evolution
- Watersoluble
- Fluidized beds
- Controlled drug delivery
- Morphology
- Pelletizing
- Separation
- Shrinkage
- Cross-sectional structures
- Drug transport
- Drug transport rates
- Ethylcellulose
- Hydroxypro-pylcellulose
- Industrial manufacturing process
- Phase-separated structures
- Porous film
- Structure evolution
- Watersoluble
- Fluidized beds
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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