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Drug release and an...
Drug release and antimicrobial property of Cellulose Nanofibril/β-Cyclodextrin/Sulfadiazine films
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- Michel, Bastien (författare)
- Université Grenoble Alpes, France
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- Heggset, Ellinor B (författare)
- RISE,Material- och ytdesign
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- Sillard, Cecile (författare)
- Université Grenoble Alpes, France
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- Syverud, Kristin (författare)
- RISE,Material- och ytdesign,NTNU, Norway
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- Dufresne, Alain (författare)
- Université Grenoble Alpes, France
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- Bras, Julien (författare)
- Université Grenoble Alpes, France
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(creator_code:org_t)
- 2023-03-17
- 2023
- Engelska.
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Ingår i: Cellulose. - : Springer Science and Business Media B.V.. - 0969-0239 .- 1572-882X. ; 30, s. 4387-
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Active Principal Ingredient (API) encapsulation through adsorption and physical entrapment onto TEMPO-oxidized cellulose nanofibrils (toCNFs) is possible, but challenges such as burst release and use of low water-soluble API such as sulfadiazine (SD) are yet to be addressed. The objective of this study is to assess the release property and antibacterial activity of toCNF/β-Cyclodextrin (β-CD)/SD materials in the form of films. Release in sink conditions was achieved with result highlighting the importance of the toCNF network structure, which is tightened at acidic pH for toCNFs due to its carboxylic content, reducing the burst effect phenomena. Antibacterial activity against Staphylococcus aureus and Escherichia coli was assessed and the results showed a clear beneficial impact of using β-CDs. An antibacterial effect for toCNF/SD films is confirmed for 3 successive applications whereas an antibacterial effect for a toCNF/CMβCD/SD film is prolonged up to 7 successive applications. The improvement of the topical release of a prophylactic agent with these materials are making them promising for biomedical applications such as wound dressing. Graphic abstract: [Figure not available: see fulltext.] © 2023, The Author(s)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- Antimicrobial properties
- Cellulose nanofibrils
- Cyclodextrins
- Drug release
- Sulfadiazine
- Cellulose films
- Escherichia coli
- Medical applications
- Nanocellulose
- Nanofibers
- Targeted drug delivery
- Active principals
- Anti-bacterial activity
- Anti-microbial properties
- Antibacterial effects
- Drug release properties
- Oxidized cellulose
- Physical entrapment
- Controlled drug delivery
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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