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Solvent strategies ...
Solvent strategies for loading and release in mesoporous silica
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- Hillerström, Anna (författare)
- RISE,Life Science,Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden
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- Andersson, Martin (författare)
- RISE,SP – Sveriges Tekniska Forskningsinstitut,Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden
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- Samuelsson, Jörgen (författare)
- Karlstads universitet,Institutionen för ingenjörs- och kemivetenskaper (from 2013),INTERACT
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- van Stam, Jan, 1958- (författare)
- Karlstads universitet,Institutionen för ingenjörs- och kemivetenskaper (from 2013),INTERACT
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(creator_code:org_t)
- Amsterdam : Elsevier BV, 2014
- 2014
- Engelska.
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Ingår i: Colloid and Interface Science Communications. - Amsterdam : Elsevier BV. - 2215-0382. ; 3, s. 5-8
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- A model molecule, ibuprofen, was loaded in the pores of mesoporous silica by adsorption from nonpolar solvents (liquid carbon dioxide and cyclohexane) and from a polar solvent (methanol). It was sufficient with a very low concentration of ibuprofen in the nonpolar solvents to achieve maximum loading of ibuprofen in the mesoporous particles. When using liquid carbon dioxide, the pores of the mesoporous silica particles were filled completely with ibuprofen at a lower ibuprofen concentration than similar experiments performed with cyclohexane. When methanol was used, the maximum amount of loaded ibuprofen was never achieved. Furthermore, x-ray scattering showed that all ibuprofen loaded into the mesoporous particles were in an amorphous state. Ibuprofen was released from the mesoporous particles to water within a couple of minutes, regardless of solvent used for loading. It was found that the release of ibuprofen from mesoporous silica was much faster than that of crystalline ibuprofen.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- Mesoporous silica
- Green solvents
- Liquid carbon dioxide
- Adsorption isotherm
- Kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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