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Evaluation of centr...
Evaluation of central venous catheters coated with a noble metal alloy - A randomized clinical pilot study of coating durability, performance and tolerability
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- Björling, Gunilla (författare)
- Röda Korsets Högskola,Hälsovetenskapliga institutionen,Karolinska Institutet
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- Johansson, Dorota (författare)
- Bactiguard, Stockholm
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- Bergström, Linda (författare)
- Bactiguard, Stockholm
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visa fler...
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- Strekalovsky, Anton (författare)
- Karolinska University Hospital
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- Sanchez, Javier (författare)
- Karolinska Institutet / Bactiguard, Stockholm
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- Frostell, Claes (författare)
- Karolinska Institutet
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- Kalman, Sigridur (författare)
- Karolinska Institutet
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visa färre...
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(creator_code:org_t)
- 2017-11-06
- 2018
- Engelska.
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Ingår i: Journal of Biomedical Materials Research. Part B - Applied biomaterials. - : John Wiley & Sons. - 1552-4973 .- 1552-4981. ; 106:6, s. 2337-2344
- Relaterad länk:
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https://doi.org/10.1...
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https://www.ncbi.nlm...
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https://rkh.diva-por... (primary) (Raw object)
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The use of Central Venous Catheters (CVCs) commonly results in complications. Coatings with silver or metal alloys can reduce the risk associated with the use of CVC. We have evaluated the durability of a noble metal coated CVC (the Bactiguard Infectious Protection, BIP CVC) and compared with an uncoated CVC for clinical tolerability (Adverse Events, AEs) and performance, in order to create a baseline for a large future study. Patients undergoing major surgery, randomised at a 2:1 ratio to BIP CVC (n = 22) or standard CVC (n = 12), were catheterized 9 - 12 days, respectively. Adverse events, microbial colonization and metal release were measured.FINDINGS: There were no AEs in the BIP CVC-group, but 5 AEs occurred in 4 patients (1 patient had 2 AEs) in the standard CVC-group, p = 0.011 (whereof 3 were catheter related). The BIP CVC showed an initial release of coating metals in blood (gold, silver and palladium), which rapidly decreased and were far below Permitted Paily Exposure (PDE) for chronical use. The levels of silver concentration were far below those needed to develop microbial resistance. The performance was equal, and there was no difference concerning microbial colonization, for the two CVCs.CONCLUSION: In this pilot study the BIP CVC had significantly lower AEs and showed a comparable performance to the standard CVC. The coating was durable throughout the study length (up to 16 days) and toxicological evaluation showed good safety margins. Larger studies are needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Nyckelord
- central venous catheter
- colonization
- noble metal alloy coating
- performance
- tolerability
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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