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Differential effect...
Differential effects of resveratrol on the dilator responses of femoral arteries, ex vivo
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- Díaz, Miguel, Högskoleadjunkt (författare)
- Röda Korsets Högskola,Hälsovetenskapliga institutionen,Manchester Metropolitan University, Manchester, UK
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- Parikh, Vijay (författare)
- Manchester Metropolitan University, Manchester, UK
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- Ismail, Saira (författare)
- Manchester Metropolitan University, Manchester, UK
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- Maxamed, Raja (författare)
- Manchester Metropolitan University, Manchester, UK
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- Tye, Emily (författare)
- Manchester Metropolitan University, Manchester, UK
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- Austin, Clare (författare)
- Edge Hill University, Lancashire, UK
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- Dew, Tristan (författare)
- Manchester Metropolitan University, Manchester, UK
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- Graf, Brigitte A (författare)
- Manchester Metropolitan University, Manchester, UK
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- Vanhees, Luc (författare)
- University Leuven, Leuven, Belgium
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- Degens, Hans (författare)
- Manchester Metropolitan University, Manchester, UK / Lithuanian Sports University, Kaunas, Lithuania / University of Medicine and Pharmacy of Targu Mures, Romania.
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- Azzawi, May (författare)
- Manchester Metropolitan University, Manchester, UK
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- Engelska.
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Ingår i: Nitric oxide. - : Elsevier. - 1089-8603 .- 1089-8611. ; 92, s. 1-10
- Relaterad länk:
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https://nottingham-r...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Resveratrol is a plant-derived phytoalexin with antioxidant, anti-inflammatory and cardio-protective properties and may be a promising therapeutic intervention strategy in cardiovascular disease. Here, we investigated the acute direct effects of trans-resveratrol (RV), on acetylcholine (ACh)-induced and flow-mediated dilation (FMD) of isolated pressurized femoral arteries of young (4-month-old) and old (26-month-old) mice. Vessel exposure to RV enhanced ACh (0.01-1.0 mM)-induced dilation (p < 0.05), but not FMD (@ 5-10 μL⋅min-1) (p < 0.05) in both young and old mice. After RV incubation, acute nitric oxide (NO) production by cultured endothelial cells was increased in response to 0.01 mM ACh, but reduced by flow (5-10 μL⋅min-1; p < 0.05). In isolated femoral arteries from endothelial nitric oxide synthase knockout (eNOS-/-) mice, RV had no overall effect on flow mediated dilation, but potentiated ACh induced dilation, that was completely abolished by potassium channel blockers, Apamin and Tram 34 (p < 0.01). We demonstrate that the non-metabolised form of RV stimulates ACh-induced dilation via the NO and EDHF pathways, but not FMD by interaction with the cyclo-oxygenase pathway. Our findings have important implications in the use of RV (for both young and aged) under 'normal' non-diseased physiological states.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Nyckelord
- Ageing
- Endothelial function
- Flow
- Nitric oxide
- Pressure myography
- Resveratrol
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Díaz, Miguel, Hö ...
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Parikh, Vijay
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Ismail, Saira
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Maxamed, Raja
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Tye, Emily
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Austin, Clare
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visa fler...
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Dew, Tristan
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Graf, Brigitte A
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Vanhees, Luc
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Degens, Hans
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Azzawi, May
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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- Artiklar i publikationen
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Nitric oxide
- Av lärosätet
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Röda Korsets Högskola