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Toxicological chara...
Toxicological characterization of a novel in vivo benzo[a]lpyrene metabolite, 7-oxo-benz[d]anthracene-3,4-dicarboxylic acid anhydride
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Nordling, M M (författare)
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- Nygren, Jonas (författare)
- Södertörns högskola,Avdelning Naturvetenskap,Karolinska Institute
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- Bergman, Jan (författare)
- Södertörns högskola,Avdelning Naturvetenskap,Karolinska Institute
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Sundberg, K (författare)
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- Rafter, J J (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2002-09-27
- 2002
- Engelska.
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Ingår i: Chemical Research in Toxicology. - : American Chemical Society (ACS). - 0893-228X .- 1520-5010. ; 15:10, s. 1274-1280
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Recently, we described a new in vivo pathway in the metabolism of benzo[a]pyrene (BP) that involves an opening of the aromatic ring system. One of the products of this pathway, isolated from rat urine, was the anhydride of 7-oxo-benz[d]anthracene-3,4-dicarboxylic acid (ABADA). We have now investigated the effect of ABADA on several cellular targets, known to be important in tumor formation. ABADA was as efficient as BP-7,8-diol-9,10-epoxide in inducing direct strand breaks but not alkali labile sites in DNA in HT-29 cells and exhibited weak mutagenic activity in Salmonella typhimurium strain TA 102. The cytotoxicity of ABADA to HCT 116 cells appeared to be due to apoptosis, as caspase-3 activity and poly-ADP-ribose polymerase (PARP) cleavage was observed. COX-2 promoter activity was induced by ABADA in HCT 116 cells. In conclusion, this novel metabolic pathway may also be contributing to the carcinogenicity of BP.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
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