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Structural analysis...
Structural analysis of the lipopolysaccharide from nontypeable Haemophilus influenzae strain 1003
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- Månsson, Martin (författare)
- Södertörns högskola,Avdelning Naturvetenskap,Karolinska Institutet
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- Hood, D W (författare)
- John Radcliffe Hospital, Oxford, UK
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- Li, J J (författare)
- National Research Council of Canada, Ottawa, Ontario, Canada
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- Richards, J C (författare)
- National Research Council of Canada, Ottawa, Ontario, Canada
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- Moxon, E R (författare)
- John Radcliffe Hospital, Oxford, UK
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- Schweda, Elke K H (författare)
- Södertörns högskola,Avdelning Naturvetenskap,Karolinska Institutet
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(creator_code:org_t)
- 2002-02-14
- 2002
- Engelska.
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Ingår i: European Journal of Biochemistry. - : Wiley. - 0014-2956 .- 1432-1033. ; 269:3, s. 808-818
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Structural analysis of the lipopolysaccharide (LPS) of nontypeable Haemophilus influenzae strain 1003 has been achieved by the application of high-field NMR techniques, ESI-MS. capillary electrophoresis coupled to ESI-MS. composition and linkage analyses on O-deacylated LPS and core oligosaccharide material. It was found that the LPS contains the common structural element of H. influenzae, L-alpha-D-Hepp-(1 --> 2)-[PEtn --> 6]-L-alpha-D-Hepp-(1 --> 3)-[beta-D-Glcp-(1 --> 4)]-L-alpha-D-Hepp-(1 --> 5)-[PP Etn --> 4]-alpha-Kdop-(2 --> 6)-Lipid A. in which the beta-D-Glcp residue is substituted by phosphocholine at O-6 and an acetyl group at O-4. A second acetyl group is located at O-3 of the distal heptose residue (HepIII). HepIII is chain elongated at O-2 by either a beta-D-Glcp residue (major), lactose or sialyllactose (minor, i.e. alpha-Neu5Ac-(2 --> 3)-beta-D-Galp-(1 --> 4)-beta-D-Glcp), where a third minor acetylation site was identified at the glucose residue. Disialylated species were also detected. In addition. a minor substitution of ester-linked glycine at HepIII and Kdo was observed.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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