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RANTES promotes gro...
RANTES promotes growth and survival of human first-trimester forebrain astrocytes
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Bakhiet, M (författare)
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- Tjernlund, A (författare)
- Karolinska Institutet
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Mousa, A (författare)
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- Gad, Annica (författare)
- Karolinska Institutet,Södertörns högskola,Avdelning Naturvetenskap,Karolinska Institute
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- Strömblad, Staffan (författare)
- Karolinska Institutet,Södertörns högskola,Avdelning Naturvetenskap,Karolinska Institute
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Kuziel, W A (författare)
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- Seiger, A (författare)
- Karolinska Institutet
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- Andersson, J (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2001-01-15
- 2001
- Engelska.
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Ingår i: Nature Cell Biology. - : Springer Science and Business Media LLC. - 1465-7392 .- 1476-4679. ; 3:2, s. 150-157
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We have examined the role of alpha and beta chemokines in the promotion of the ontogenetic development of the brain. RANTES was expressed preferentially in human fetal astrocytes in an age-dependent manner. Astrocytes from 5-week-old brains showed high proliferation and reduced survival, whereas 10-week-old astrocytes exhibited opposite effects. These effects were suppressed by anti-RANTES or anti-RANTES receptor antibodies and were enhanced by recombinant RANTES. RANTES induced tyrosine phosphorylation of several cellular proteins and nuclear translocation of STAT-1 in astrocytes. Interferons (IFN-gamma) was required for RANTES effects because RANTES induced IFN-gamma, and only 10-week-old astrocytes expressed the IFN-gamma receptor. Blocking of IFN-gamma with antibody reversed the effects of RANTES, indicating that cytokine/chemokine networks are critically involved in brain development.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
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