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Transient inhibitio...
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Olsson, T G SGöteborg University
(författare)
Transient inhibition of histone deacetylase activity overcomes silencing in the mating-type region in fission yeast
- Artikel/kapitelEngelska1999
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Springer Science and Business Media LLC,1999
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LIBRIS-ID:oai:DiVA.org:sh-31263
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https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-31263URI
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https://doi.org/10.1007/s002940050436DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:15588741URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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We have investigated the effects of inhibition of histone de-acetylase activity on silencing at the silent mating-type loci in fission yeast. Treatment of exponentially growing cells with the histone deacetylase inhibitor, trichostatin A (TSA), resulted in derepression of a marker gene inserted 150 bp distal from the silent mat3-M locus. The natural targets for the silencing mechanism in this region were only partially derepressed and the activation appeared to be asymmetric. i.e. the mat2-P cassette remained silent at concentrations that clearly partially derepressed the mat3-M cassette. We further noted that treatment of wild-type h(90) cells resulted in the generation of altered sporulation phenotypes, indicating that the treatment affected the expression of mating-type genes and/or mating-type switching. The results are discussed in the light of recent accumulated data regarding the role of deacetylation for silencing in other species.
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Silverstein, Rebecka A.Karolinska Institutet(Swepub:sh)SHRASN
(författare)
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Ekwall, KarlKarolinska Institutet(Swepub:sh)SHKLEL
(författare)
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Sunnerhagen, PGöteborg University
(författare)
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Göteborg UniversityKarolinska Institutet
(creator_code:org_t)
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Ingår i:Current Genetics: Springer Science and Business Media LLC35:2, s. 82-870172-80831432-0983
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