Feasibility aspects of exploring exercise-induced neuroplasticity in Parkinson's disease: A pilot randomized controlled trial

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Feasibility aspects of exploring exercise-induced neuroplasticity in Parkinson's disease : A pilot randomized controlled trial

Johansson, Hanna (författare): Karolinska Institutet,Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden;Medical Unit Occupational Therapy & Physiotherapy, Allied Health Professionals Function, Karolinska University Hospital, Stockholm, Sweden

Freidle, Malin (författare): Karolinska Institutet

Ekman, Urban (författare): Karolinska Institutet

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Schalling, Ellika (författare): Karolinska Institutet

Leavy, Breiffni (författare): Karolinska Institutet

Svenningsson, Per (författare): Karolinska Institutet

Hagströmer, Maria (författare): Karolinska Institutet,Sophiahemmet Högskola

Franzén, Erika (författare): Karolinska Institutet

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Hindawi Limited, 2020
2020
Engelska.
Ingår i: Parkinson's Disease. - : Hindawi Limited. - 2090-8083 .- 2042-0080. ; 2020

Relaterad länk:: https://shh.diva-por... (primary) (Raw object); visa fler...; https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://urn.kb.se/re...; visa färre...

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Background: Recent studies indicate that exercise can induce neuroplastic changes in people with Parkinson's disease (PwPD). Reports of feasibility outcomes from existing pilot trials however are, of date, insufficient to enable replication by others in larger definitive trials.Objective: To evaluate trial design for a definitive trial by exploring process and scientific feasibility.Methods: The trial design was a parallel-group RCT pilot with a 1 : 1 allocation ratio to either HiBalance or an active control group (HiCommunication). Both groups received one-hour sessions twice weekly, plus home exercises weekly, for 10 weeks. Participants with mild-to-moderate Parkinson's disease (PD) were recruited via advertisement. Assessment included physical performance, structural and functional MRI, blood sampling, neuropsychological assessment, and speech/voice assessment. Process and scientific feasibility were monitored throughout the study. Process feasibility involved recruitment, participant acceptability of assessments and interventions, assessment procedures (focus on imaging, blood sampling, and dual-task gait analysis), and blinding procedures. Scientific feasibility involved trends in outcome response and safety during group training and home exercises. Data are presented in median, minimum, and maximum values. Changes from pre- to postintervention are reported descriptively.Results: Thirteen participants were included (4 women, mean age 69.7 years), with a recruitment rate of 31%. Attendance rates and follow-up questionnaires indicated that both groups were acceptable to participate. Image quality was acceptable; however, diplopia and/or sleepiness were observed in several participants during MRI. With regard to dual-task gait performance, there appeared to be a ceiling effect of the cognitive tasks with seven participants scoring all correct answers at pretest. Blinding of group allocation was successful for one assessor but was broken for half of participants for the other.Conclusions: The overall trial design proved feasible to perform, but further strengthening ahead of the definitive RCT is recommended, specifically with respect to MRI setup, cognitive dual-tasks during gait, and blinding procedures. This trial is registered with NCT03213873.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Sjukgymnastik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Physiotherapy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)

Nyckelord

Parkinson's disease
Exercise

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Av författaren/redakt...: Johansson, Hanna; Freidle, Malin; Ekman, Urban; Schalling, Ellik ...; Leavy, Breiffni; Svenningsson, Pe ...; visa fler...; Hagströmer, Mari ...; Franzén, Erika; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Sjukgymnastik

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap

Artiklar i publikationen: Parkinson's Dise ...

Av lärosätet: Sophiahemmet Högskola; Karolinska Institutet; Uppsala universitet

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