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The Sec62-Sec63 tra...
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Jung, Sung-Jun
(författare)
The Sec62-Sec63 translocon facilitates translocation of the C-terminus of membrane proteins
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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2014-01-01
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The Company of Biologists,2014
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:su-109278
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-109278URI
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https://doi.org/10.1242/jcs.153650DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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AuthorCount:4;
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The Sec62-Sec63 complex mediates post-translational translocation of a subset of primarily secretory proteins into the endoplasmic reticulum (ER) in yeast. Therefore, it has been thought that membrane proteins, which are mainly co-translationally targeted into the ER, are not handled by the Sec62-Sec63 translocon. By systematic analysis of single and multi-spanning membrane proteins with broad sequence context [with differing hydrophobicity, flanking charged residues and orientation of transmembrane (TM) segments], we show that mutations in the N-terminal cytosolic domain of yeast Sec62 impair its interaction with Sec63 and lead to defects in membrane insertion and translocation of the C-terminus of membrane proteins. These results suggest that there is an unappreciated function of the Sec62-Sec63 translocon in regulating topogenesis of membrane proteins in the eukaryotic cell.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kim, Ji Eun Hani
(författare)
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Reithinger, Johannes H.Stockholms universitet,Institutionen för biokemi och biofysik
(författare)
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Kim, Hyun
(författare)
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Stockholms universitetInstitutionen för biokemi och biofysik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Cell Science: The Company of Biologists127:19, s. 4270-42780021-95331477-9137
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