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Age differences in ...
Age differences in brain systems supporting transient and sustained processes involved in prospective memory and working memory
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- Peira, Nathalie (författare)
- Uppsala universitet,Stockholms universitet,Perception och psykofysik,Department of Psychology, Uppsala University, Uppsala, Sweden; Department of Psychology, Stockholm University, Stockholm, Sweden,Institutionen för psykologi,Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden.
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- Ziaei, Maryam (författare)
- School of Psychology, The University of QLD, St Lucia, Australia,Univ QLD, Sch Psychol, St Lucia, Qld 4072, Australia.
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- Persson, Jonas, 1971- (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Kognitiv psykologi,Department of Psychology, Stockholm University, Stockholm, Sweden; Aging Research Center (ARC) at Karolinska Institute and Stockholm University, Stockholm, Sweden,Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden.;Karolinska Inst, Aging Res Ctr ARC, S-11330 Stockholm, Sweden.;Stockholm Univ, S-11330 Stockholm, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: NeuroImage. - : Elsevier BV. - 1053-8119 .- 1095-9572. ; 125, s. 745-755
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Abstract
Ämnesord
Stäng
- In prospective memory (PM), an intention to act in response to an external event is formed, retained, and at a later stage, when the event occurs, the relevant action is performed. PM typically shows a decline in late adulthood, which might affect functions of daily living. The neural correlates of this decline are not well understood. Here, 15 young (6 female; age range = 23-30 years) and 16 older adults (5 female; age range = 64-74 years) were scanned with fMRI to examine age-related differences in brain activation associated with event-based PM using a task that facilitated the separation of transient and sustained components of PM. We show that older adults had reduced performance in conditions with high demands on prospective and working memory, while no age-difference was observed in low-demanding tasks. Across age groups, PM task performance activated separate sets of brain regions for transient and sustained responses. Age-differences in transient activation were found in fronto-striatal and MTL regions, with young adults showing more activation than older adults. Increased activation in young, compared to older adults, was also found for sustained PM activation in the IFG. These results provide new evidence that PM relies on dissociable transient and sustained cognitive processes, and that age-related deficits in PM can be explained by an inability to recruit PM-related brain networks in old age.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- fMRI
- aging
- working memory
- prospective memory
- Psychology
- psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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