Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene

Mazari, Aslam M. A.Stockholms universitet,Institutionen för neurokemi (författare)

The nitroaromatic explosive 2,4,6-trinitrotoluene (TNT) and the related 2,4-dinitrotoluene (DNT) aretoxic environmental pollutants. The biotransformation and detoxication of these persistent compoundsin higher organisms are of great significance from a health perspective as well as for the biotechnological challenge of bioremediation of contaminated soil. We demonstrate that different human glutathionetransferases (GSTs) and GSTs from the fruit fly Drosophila melanogaster are catalysts of the biotransformationof TNT and DNT. The human GSTs had significant but modest catalytic activities with both DNT and TNT. However, D. melanogaster GSTE6 and GSTE7 displayed outstanding high activities withboth substrates.

NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
NATURVETENSKAP Kemi hsv//swe
NATURAL SCIENCES Chemical Sciences hsv//eng
Glutathione conjugation
2
4
6-trinitrotoluene detoxication
2
4-dinitrotoluene detoxication
Drosophila GSTs
Human GSTs
neurokemi med molekylär neurobiologi
Neurochemistry with Molecular Neurobiology

Mannervik, BengtStockholms universitet,Institutionen för neurokemi(Swepub:su)bmann (författare)
Stockholms universitetInstitutionen för neurokemi (creator_code:org_t)

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