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BOLD Variability is...
BOLD Variability is Related to Dopaminergic Neurotransmission and Cognitive Aging
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- Guitart-Masip, Marc (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University College London, UK
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- Salami, Alireza (författare)
- Karolinska Institutet,Umeå universitet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå Center for Functional Brain Imaging, Sweden,Umeå centrum för funktionell hjärnavbildning (UFBI),Aging Research Center, Karolinska Institute, Stockholm, Sweden
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Garrett, Douglas (författare)
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- Rieckmann, Anna (författare)
- Center for Brain Science, Harvard University, Cambridge, USA
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Lindenberger, Ulman (författare)
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- Bäckman, Lars (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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(creator_code:org_t)
- 2015-03-05
- 2016
- Engelska.
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Ingår i: Cerebral Cortex. - : Oxford University Press (OUP). - 1047-3211 .- 1460-2199. ; 26:5, s. 2074-2083
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Dopamine (DA) losses are associated with various aging-related cognitive deficits. Typically, higher moment-to-moment brain signal variability in large-scale patterns of voxels in neocortical regions is linked to better cognitive performance and younger adult age, yet the physiological mechanisms regulating brain signal variability are unknown. We explored the relationship among adult age, DA availability, and blood oxygen level-dependent (BOLD) signal variability, while younger and older participants performed a spatial working memory (SWM) task. We quantified striatal and extrastriatal DA D1 receptor density with [C-11]SCH23390 and positron emission tomography in all participants. We found that BOLD variability in a neocortical region was negatively related to age and positively related to SWM performance. In contrast, BOLD variability in subcortical regions and bilateral hippocampus was positively related to age and slower responses, and negatively related to D1 density in caudate and dorsolateral prefrontal cortex. Furthermore, BOLD variability in neocortical regions was positively associated with task-related disengagement of the default-mode network, a network whose activation needs to be suppressed for efficient SWM processing. Our results show that age-related DA losses contribute to changes in brain signal variability in subcortical regions and suggest a potential mechanism, by which neocortical BOLD variability supports cognitive performance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- BOLD variability
- cognitive aging
- default mode network
- dopamine
- spatial working memory
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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