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Inflammatory markers and exposure to airborne particles among workers in a Swedish pulp and paper mill
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- Westberg, Håkan (författare)
- Örebro University Hospital, Sweden
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- Elihn, Karine (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Stockholm University, Sweden
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- Andersson, Eva (författare)
- Sahlgrens University Hospital, Sweden
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- Persson, Bodil (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Region Östergötland, Arbets- och miljömedicin,Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, Lund, Sweden
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- Andersson, Lennart (författare)
- Örebro University Hospital, Sweden
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- Bryngelsson, Ing-Liss (författare)
- Örebro University Hospital, Sweden
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- Karlsson, Cathe (författare)
- Billerud AB, Sweden
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- Sjögren, Bengt (författare)
- Karolinska Institutet,Karolinska Institute, Sweden
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(creator_code:org_t)
- 2016-02-13
- Engelska.
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Ingår i: International Archives of Occupational and Environmental Health. - : Springer Science and Business Media LLC. - 0340-0131 .- 1432-1246. ; 89:5, s. 813-822
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Abstract
Ämnesord
Stäng
- To study the relationship between exposure to airborne particles in a pulp and paper mill and markers of inflammation and coagulation in blood. Personal sampling of inhalable dust was performed for 72 subjects working in a Swedish pulp and paper mill. Stationary measurements were used to study concentrations of total dust, respirable dust, PM10 and PM2.5, the particle surface area and the particle number concentrations. Markers of inflammation, interleukins (IL-1b, IL-6, IL-8, and IL-10), C-reactive protein (CRP), serum amyloid A (SAA), and fibrinogen and markers of coagulation factor VIII, von Willebrand, plasminogen activator inhibitor, and D-dimer were measured in plasma or serum. Sampling was performed on the last day of the work free period of 5 days, before and after the shift the first day of work and after the shifts the second and third day. In a mixed model analysis, the relationship between particulate exposures and inflammatory markers was determined. Sex, age, smoking, and BMI were included as covariates. The average 8-h time-weighted average (TWA) air concentration levels of inhalable dust were 0.30 mg/m(3), range 0.005-3.3 mg/m(3). The proxies for average 8-h TWAs of respirable dust were 0.045 mg/m(3). Significant and consistent positive relations were found between several exposure metrics (PM 10, total and inhalable dust) and CRP, SAA and fibrinogen taken post-shift, suggesting a dose-effect relationship. This study supports a relationship between occupational particle exposure and established inflammatory markers, which may indicate an increased risk of cardiovascular disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- C-reactive protein (CRP)
- Fibrinogen
- Interleukins (IL-1b
- IL-6 IL-8 and IL-10)
- PM10
- PM2.5
- Respirable dust
- Serum amyloid A (SAA)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)