Sökning: onr:"swepub:oai:DiVA.org:su-143574" > ADAR2 regulates RNA...
Fältnamn | Indikatorer | Metadata |
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000 | 03347naa a2200481 4500 | |
001 | oai:DiVA.org:su-143574 | |
003 | SwePub | |
008 | 170601s2017 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1435742 URI |
024 | 7 | a https://doi.org/10.1093/nar/gkw13042 DOI |
040 | a (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Anantharaman, Aparna4 aut |
245 | 1 0 | a ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins |
264 | c 2017-01-03 | |
264 | 1 | b Oxford University Press (OUP),c 2017 |
338 | a print2 rdacarrier | |
520 | a Adenosine deaminases acting on RNA (ADARs) catalyze the editing of adenosine residues to inosine (A-to-I) within RNA sequences, mostly in the introns and UTRs (un-translated regions). The significance of editing within non-coding regions of RNA is poorly understood. Here, we demonstrate that association of ADAR2 with RNA stabilizes a subset of transcripts. ADAR2 interacts with and edits the 3' UTR of nuclear-retained Cat2 transcribed nuclear RNA (Ctn RNA). In absence of ADAR2, the abundance and half-life of Ctn RNA are significantly reduced. Furthermore, ADAR2-mediated stabilization of Ctn RNA occurred in an editing-independent manner. Unedited Ctn RNA shows enhanced interaction with the RNA-binding proteins HuR and PARN [Poly(A) specific ribonuclease deadenylase]. HuR and PARN destabilize Ctn RNA in absence of ADAR2, indicating that ADAR2 stabilizes Ctn RNA by antagonizing its degradation by PARN and HuR. Transcriptomic analysis identified other RNAs that are regulated by a similar mechanism. In summary, we identify a regulatory mechanism whereby ADAR2 enhances target RNA stability by limiting the interaction of RNA-destabilizing proteins with their cognate substrates. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
700 | 1 | a Tripathi, Vidisha4 aut |
700 | 1 | a Khan, Abid4 aut |
700 | 1 | a Yoon, Je-Hyun4 aut |
700 | 1 | a Singh, Deepak K.4 aut |
700 | 1 | a Gholamalamdari, Omid4 aut |
700 | 1 | a Guang, Shuomeng4 aut |
700 | 1 | a Ohlson, Johanu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut |
700 | 1 | a Wahlstedt, Heleneu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut |
700 | 1 | a Öhman, Marieu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)marohm |
700 | 1 | a Jantsch, Michael F.4 aut |
700 | 1 | a Conrad, Nicholas K.4 aut |
700 | 1 | a Ma, Jian4 aut |
700 | 1 | a Gorospe, Myriam4 aut |
700 | 1 | a Prasanth, Supriya G.4 aut |
700 | 1 | a Prasanth, Kannanganattu V.4 aut |
710 | 2 | a Stockholms universitetb Institutionen för molekylär biovetenskap, Wenner-Grens institut4 org |
773 | 0 | t Nucleic Acids Researchd : Oxford University Press (OUP)g 45:7, s. 4189-4201q 45:7<4189-4201x 0305-1048x 1362-4962 |
856 | 4 | u https://academic.oup.com/nar/article-pdf/45/7/4189/16965510/gkw1304.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-143574 |
856 | 4 8 | u https://doi.org/10.1093/nar/gkw1304 |
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