Sökning: onr:"swepub:oai:DiVA.org:su-146949" >
Persistent organic ...
Persistent organic pollutants in infants and toddlers : Relationship between concentrations in matched plasma and faecal samples
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
-
Elsevier BV,2017
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:su-146949
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-146949URI
-
https://doi.org/10.1016/j.envint.2017.06.019DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to POPs. The concentrations of selected POPs were measured in matched plasma and faecal samples collected from 20 infants/toddlers (aged 13 +/- 4.8 months), including a repeat sample time point for 13 infants (similar to 5 months apart). We observed higher rates of POP quantification in faeces (2 g dry weight) than in plasma (0.5 mL). Among the five chemicals that had quantification frequencies over 50% in both matrices, except for HCB, log concentration in faeces (C-f) and blood (C-b) were correlated (r > 0.74, P < 0.05) for p.p'-dichlorodiphenyldichloroethylene (p,p'-DDE), 2,3', 4,4', 5-pentachlorobiphenyl (PCB118), 2,2', 3,4,4', 5'-pentachlorobiphenyl (PCB138) and 2,2', 4,4', 5,5'-pentachlorobiphenyl (PCB153). We determined faeces: plasma concentration ratios (K-fb), which can be used to estimate C-b from measurements of C-f for infants/toddlers. For a given chemical, the variation in K-fb across individuals was considerable (CV from 0.46 to 0.70). Between 5% and 50% of this variation was attributed to short-term intra-individual variability between successive faecal samples. This variability could be reduced by pooling faeces samples over several days. Some of the remaining variability was attributed to longer-term intra-individual variability, which was consistent with previously reported observations of a decrease in K-fb over the first year of life. The strong correlations between C-f and C-b demonstrate the promise of using faeces for biomonitoring of these compounds. Future research on the sources of variability in K-fb could improve the precision and utility of this technique.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Sjodin, Andreas
(författare)
-
McLachlan, Michael S.Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi(Swepub:su)mmcla
(författare)
-
English, Karin
(författare)
-
Aylward, Lesa L.
(författare)
-
Toms, Leisa-Maree L.
(författare)
-
Varghese, Julie
(författare)
-
Sly, Peter D.
(författare)
-
Mueller, Jochen F.
(författare)
-
Stockholms universitetInstitutionen för miljövetenskap och analytisk kemi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Environment International: Elsevier BV107, s. 82-880160-41201873-6750
Internetlänk
Hitta via bibliotek
Till lärosätets databas