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Cholesterol and tri...
Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults.
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- de Frias, Cindy M. (författare)
- Stockholms universitet,Psykologiska institutionen
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Bunce, David (författare)
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- Wahlin, Åke (författare)
- Stockholms universitet,Psykologiska institutionen
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- Adolfsson, Rolf (författare)
- Umeå universitet,Psykiatri
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Sleegers, Kristel (författare)
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Cruts, Marc (författare)
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Van Broeckhoven, Christine (författare)
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- Nilsson, Lars-Göran (författare)
- Stockholms universitet,Psykologiska institutionen
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(creator_code:org_t)
- Washington : The gerontological society of America, 2007
- 2007
- Engelska.
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Ingår i: Journal of Gerontology: Psychological Sciences. - Washington : The gerontological society of America. - 1079-5014 .- 1758-5368. ; 62B:2, s. P112-P118
- Relaterad länk:
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- We used data from the Betula Study to examine associations between total cholesterol, triglycerides, and apolipoprotein E on 10-year changes in cognitive performance. Tests assessing episodic memory (recall and recognition), semantic memory (knowledge and fluency), and visuospatial ability (block design) were administered to 524 nondemented adults (initial age of 55-80 years); multilevel modeling was applied to the data. Higher triglyceride levels were associated with a decline in verbal knowledge. Lipid levels moderated the influence of apolipoprotein E on episodic memory, such that among epsilon 4 allele carriers, decline in recognition was noted for individuals with higher cholesterol levels. Cholesterol and triglyceride levels are pharmacologically modifiable risk factors that account for variation In normal cognitive aging.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- vascular risk factors
- e4 allele
- Alzheimer's disease
- cognitive decline
- APOE genotype
- serum cholesterol
- declarative memory
- prospective cohort
- blood pressure
- population
- Psychology
- Psykologi
- Psychology
- psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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