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Amygdala-orbitofron...
Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder
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- Lindner, Philip (författare)
- Stockholms universitet,Klinisk psykologi,Karolinska Institutet, Sweden; Stockholm Center for Dependence Disorders, Stockholm County Council, Sweden,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Stockholm Cty Council, Stockholm Ctr Dependence Disorders, Stockholm, Sweden.;Stockholm Univ, Dept Psychol, Stockholm, Sweden.
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- Flodin, Pär (författare)
- Karolinska Institutet,Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Enheten för demografi och åldrandeforskning (CEDAR),Umea Univ, Umea Ctr Funct Brain Imaging, Umea, Sweden.;Umea Univ, Ctr Aging & Demog Res, Umea, Sweden.
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- Peter, Larm (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Budhiraja, Meenal (författare)
- Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
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- Savic-Berglund, Ivanka (författare)
- Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Karolinska Univ Hosp, Neurol Clin, Huddinge, Sweden.
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- Jokinen, Jussi (författare)
- Karolinska Institutet,Umeå universitet,Institutionen för klinisk vetenskap,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Umea Univ, Dept Clin Sci, Umea, Sweden.
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- Tiihonen, Jari (författare)
- Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Univ Eastern Finland, Niuvanniemi Hosp, Dept Forens Psychiat, Kuopio, Finland.
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- Hodgins, Sheilagh (författare)
- Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Univ Montreal, Dept Psychiat, Montreal, PQ, Canada.
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(creator_code:org_t)
- 2018-01-18
- 2018
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8
- Relaterad länk:
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https://doi.org/10.1...
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https://www.nature.c...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Conduct disorder (CD) and anxiety disorders (ADs) are often comorbid and both are characterized by hyper-sensitivity to threat, and reduced structural and functional connectivity between the amygdala and orbitofrontal cortex (OFC). Previous studies of CD have not taken account of ADs nor directly compared connectivity in the two disorders. We examined three groups of young women: 23 presenting CD and lifetime AD; 30 presenting lifetime AD and not CD; and 17 with neither disorder (ND). Participants completed clinical assessments and diffusion-weighted and resting-state functional MRI scans. The uncinate fasciculus was reconstructed using tractography and manual dissection, and structural measures extracted. Correlations of resting-state activity between amygdala and OFC seeds were computed. The CD + AD and AD groups showed similarly reduced structural integrity of the left uncinate compared to ND, even after adjusting for IQ, psychiatric comorbidity, and childhood maltreatment. Uncinate integrity was associated with harm avoidance traits among AD-only women, and with the interaction of poor anger control and anxiety symptoms among CD + AD women. Groups did not differ in functional connectivity. Reduced uncinate integrity observed in CD + AD and AD-only women may reflect deficient emotion regulation in response to threat, common to both disorders, while other neural mechanisms determine the behavioral response.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- aggression
- amygdala
- anxiety
- human behaviour
- prefrontal cortex
- Psychology
- psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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