Sökning: onr:"swepub:oai:DiVA.org:su-153799" >
Perfluoroalkyl acid...
Perfluoroalkyl acid levels in first-time mothers in relation to offspring weight gain and growth
-
Gyllenhammar, Irina (författare)
-
- Diderholm, Barbro, 1965- (författare)
- Uppsala universitet,Barnendokrinologisk forskning
-
- Gustafsson, Jan, 1948- (författare)
- Uppsala universitet,Barnendokrinologisk forskning
-
visa fler...
-
- Berger, Urs (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Helmholtz Centre for Environmental Research – UFZ, Germany
-
- Ridefelt, Peter (författare)
- Uppsala universitet,Klinisk kemi
-
- Benskin, Jonathan P. (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
-
Lignell, Sanna (författare)
-
- Lampa, Erik, 1977- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
-
Glynn, Anders (författare)
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
-
Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 111, s. 191-199
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://doi.org/10.1...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- We investigated if maternal body burdens of perfluoroalkyl acids (PFAAs) at the time of delivery are associated with birth outcome and if early life exposure (in utero/nursing) is associated with early childhood growth and weight gain. Maternal PFAA body burdens were estimated by analysis of serum samples from mothers living in Uppsala County, Sweden (POPUP), sampled three weeks after delivery between 1996 and 2011. Data on child length and weight were collected from medical records and converted into standard deviation scores (SDS). Multiple linear regression models with appropriate covariates were used to analyze associations between maternal PFAA levels and birth outcomes (n = 381). After birth Generalized Least Squares models were used to analyze associations between maternal PFAA and child growth (n = 200). Inverse associations were found between maternal levels of perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA), and birth weight SDS with a change of - 0.10 to - 0.18 weight SDS for an inter-quartile range (IQR) increase in ng/g PFAA. After birth, weight and length SDS were not significantly associated with maternal PFAA. However, BMI SDS was significantly associated with PFOA, PFNA, and PFHxS at 3 and 4 years of age, and with PFOS at 4 and 5 years of age. If causal, these associations suggest that PFAA affects fetal and childhood body development in different directions.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Gyllenhammar, Ir ...
-
Diderholm, Barbr ...
-
Gustafsson, Jan, ...
-
Berger, Urs
-
Ridefelt, Peter
-
Benskin, Jonatha ...
-
visa fler...
-
Lignell, Sanna
-
Lampa, Erik, 197 ...
-
Glynn, Anders
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Geovetenskap och ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
Environment Inte ...
- Av lärosätet
-
Stockholms universitet
-
Uppsala universitet