Sökning: onr:"swepub:oai:DiVA.org:su-157752" >
Metals and Parkinso...
Metals and Parkinson's Disease : Mechanisms and Biochemical Processes
-
Bjorklund, Geir (författare)
-
- Stejskal, Vera (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
-
Urbina, Mauricio A. (författare)
-
visa fler...
-
Dadar, Maryam (författare)
-
Chirumbolo, Salvatore (författare)
-
Mutter, Joachim (författare)
-
visa färre...
-
(creator_code:org_t)
- Bentham Science Publishers Ltd. 2018
- 2018
- Engelska.
-
Ingår i: Current Medicinal Chemistry. - : Bentham Science Publishers Ltd.. - 0929-8673 .- 1875-533X. ; 25:19, s. 2198-2214
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.2...
-
visa färre...
Abstract
Ämnesord
Stäng
- Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease (PD), while the remaining cases are of unknown etiology. It is believed that environmental factors may be involved in the causality of a large proportion of PD cases. Several PD genes are activated by xenobiotic exposure, and a link between pesticide exposure and PD has been demonstrated. Many epidemiological studies have shown an association between PD and exposure to metals such as mercury, lead, manganese, copper, iron, aluminum, bismuth, thallium, and zinc. This review explores the biological effects, the pathogenetic processes, genetic susceptibilities to metals as well as examining future strategies for PD treatment, such as chelation therapy.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- Substantia nigra
- alpha-synuclein
- beta-amyloid
- glutamate
- glutathione
- oxidative stress
- metals
- dopamine
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas