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Amygdala reactivity...
Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder
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- Kraus, Jakub (författare)
- Karolinska Inst, Dept Clin Neurosci, Nobels Vag 9, Stockholm, Sweden;Masaryk Univ, Cent European Inst Technol, Ctr Neurosci, Brno, Czech Republic;Masaryk Univ, Fac Med, Brno, Czech Republic
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- Frick, Andreas (författare)
- Uppsala universitet,Stockholms universitet,Biologisk psykologi,Uppsala University, Sweden,Institutionen för psykologi,Masaryk Univ, Fac Med, Brno, Czech Republic
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- Fischer, Håkan (författare)
- Stockholms universitet,Biologisk psykologi,Stockholm Univ, Dept Psychol, Stockholm, Sweden
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- Howner, Katarina (författare)
- Karolinska Institutet
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- Fredriksson, Mats (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Clin Neurosci, Nobels Vag 9, Stockholm, Sweden
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- Furmark, Tomas (författare)
- Uppsala universitet,Institutionen för psykologi
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Psychiatry Research. - : Elsevier BV. - 0925-4927 .- 1872-7506. ; 280, s. 56-61
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Social anxiety disorder (SAD) is characterized by exaggerated amygdala reactivity in response to symptom provocation, but it is unclear if such hyper-reactivity is elicited by disorder-specific challenges only or characterizes reactions to aversive stimuli in general. Here, using functional magnetic resonance imaging in 14 patients with SAD, as compared to 12 healthy controls, we found that amygdala hyper-reactivity is confined to disorder-relevant social stimulation. SAD patients displayed increased amygdala reactivity to fearful as compared to neutral facial pictures, but not in response to generally aversive but mainly non-social stimulation when compared to neutral pictorial stimuli taken from the International Affective Picture System. The increased amygdala reactivity was not mediated by an altered prefrontal inhibition among SAD patients as compared to controls, suggesting increased bottom-up processes rather than attenuated top-down control. In conclusion, the enhanced amygdala reactivity in SAD seems specific to socially relevant stimuli rather than aversive stimuli in general.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- social phobia
- emotional faces
- International Affective Picture System
- IAPS
- fMRI
- fear
- Psychology
- psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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