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Brain glial activat...
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Albrecht, Daniel S.Karolinska Institutet
(författare)
Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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Elsevier BV,2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:su-163829
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-163829URI
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https://doi.org/10.1016/j.bbi.2018.09.018DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440717URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139884334URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests a role for neuroinflammation, no study has directly provided evidence of brain glial activation in FM. In this study, we conducted a Positron Emission Tomography (PET) study using [C-11]PBR28, which binds to the translocator protein (TSPO), a protein upregulated in activated microglia and astrocytes. To enhance statistical power and generalizability, we combined datasets collected independently at two separate institutions (Massachusetts General Hospital [MGH] and Karolinska Institutet [KI]). In an attempt to disentangle the contributions of different glial cell types to FM, a smaller sample was scanned at KI with [C-11]-L-deprenyl-D2 PET, thought to primarily reflect astrocytic (but not microglial) signal. Thirty-one FM patients and 27 healthy controls (HC) were examined using [C-11]PBR28 PET. 11 FM patients and 11 HC were scanned using [C-11]-L-deprenyl-D2 PET. Standardized uptake values normalized by occipital cortex signal (SUVR) and distribution volume (V-T) were computed from the [C-11]PBR28 data. [C-11]-L-deprenyl-D2 was quantified using lambda k(3). PET imaging metrics were compared across groups, and when differing across groups, against clinical variables. Compared to HC, FM patients demonstrated widespread cortical elevations, and no decreases, in [C-11]PBR28 ITT and SUVR, most pronounced in the medial and lateral walls of the frontal and parietal lobes. No regions showed significant group differences in [C-11]-L-deprenyl-Ds signal, including those demonstrating elevated [C-11] PBR28 signal in patients (p's >= 0.53, uncorrected). The elevations in [C-11]PBR28 V-T and SUVR were correlated both spatially (i.e., were observed in overlapping regions) and, in several areas, also in terms of magnitude. In exploratory, uncorrected analyses, higher subjective ratings of fatigue in FM patients were associated with higher [C-11] PBR28 SUVR in the anterior and posterior middle cingulate cortices (p's < 0.03). SUVR was not significantly associated with any other clinical variable. Our work provides the first in vivo evidence supporting a role for glial activation in FM pathophysiology. Given that the elevations in [C-11]PBR28 signal were not also accompanied by increased [C-11]-deprenyl-D2 signal, our data suggests that microglia, but not astrocytes, may be driving the TSPO elevation in these regions. Although [C-11]-L-deprenyl-D2 signal was not found to be increased in FM patients, larger studies are needed to further assess the role of possible astrocytic contributions in FM. Overall, our data support glial modulation as a potential therapeutic strategy for FM.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Forsberg, AntonKarolinska Institutet
(författare)
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Sandstrom, AngelicaKarolinska Inst, Dept Clin Neurosci, Nobels Vag 9, S-17177 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neuroradiol, Stockholm, Sweden.
(författare)
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Bergan, CourtneyHarvard Med Sch, AA Martinos Ctr Biomed Imaging, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA.
(författare)
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Kadetoff, DianaKarolinska Inst, Dept Clin Neurosci, Nobels Vag 9, S-17177 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neuroradiol, Stockholm, Sweden.;Stockholm Spine Ctr, Stockholm, Sweden.
(författare)
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Protsenko, EkaterinaHarvard Med Sch, AA Martinos Ctr Biomed Imaging, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA.
(författare)
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Lampa, JonKarolinska Institutet
(författare)
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Lee, Yvonne C.Harvard Med Sch, Div Rheumatol, Brigham & Womens Hosp, Boston, MA USA.;Northwestern Univ, Div Rheumatol, Feinberg Sch Med, Chicago, IL 60611 USA.,Harvard Med Sch, AA Martinos Ctr Biomed Imaging, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA.
(författare)
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Hoglund, Caroline OlgartKarolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
(författare)
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Catana, CiprianKarolinska Institutet
(författare)
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Cervenka, SimonKarolinska Institutet(Swepub:uu)simce160
(författare)
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Akeju, OluwaseunHarvard Med Sch, Dept Anesthesia Crit Care & Pain Med, Massachusetts Gen Hosp, Boston, MA USA.
(författare)
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Lekander, MatsStockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden; Karolinska University Hospital, Sweden,Karolinska Inst, Dept Clin Neurosci, Nobels Vag 9, S-17177 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neuroradiol, Stockholm, Sweden.;Stockholm Univ, Stress Res Inst, Stockholm, Sweden.(Swepub:su)mleka
(författare)
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Cohen, GeorgeHarvard Med Sch, Dept Rheumatol, Massachusetts Gen Hosp, Boston, MA USA.
(författare)
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Halldin, ChristerKarolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, SE-17176 Stockholm, Sweden.;Stockholm Cty Council, SE-17176 Stockholm, Sweden.
(författare)
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Taylor, NormanHarvard Med Sch, Dept Anesthesia Crit Care & Pain Med, Massachusetts Gen Hosp, Boston, MA USA.
(författare)
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Kim, MinhaeHarvard Med Sch, Dept Rheumatol, Massachusetts Gen Hosp, Boston, MA USA.
(författare)
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Hooker, Jacob M.Harvard Med Sch, Dept Rheumatol, Massachusetts Gen Hosp, Boston, MA USA.
(författare)
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Edwards, Robert R.Harvard Med Sch, Dept Anesthesiol, Brigham & Womens Hosp, Boston, MA USA.
(författare)
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Napadow, VitalyHarvard Med Sch, AA Martinos Ctr Biomed Imaging, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA.;Harvard Med Sch, Dept Anesthesiol, Brigham & Womens Hosp, Boston, MA USA.
(författare)
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Kosek, EvaKarolinska Institutet(Swepub:uu)evako353
(författare)
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Loggia, Marco L.Harvard Med Sch, AA Martinos Ctr Biomed Imaging, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA.
(författare)
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Karolinska InstitutetKarolinska Inst, Dept Clin Neurosci, Nobels Vag 9, S-17177 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neuroradiol, Stockholm, Sweden.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Brain, behavior, and immunity: Elsevier BV75, s. 72-830889-15911090-2139
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Albrecht, Daniel ...
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Forsberg, Anton
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Sandstrom, Angel ...
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Bergan, Courtney
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Kadetoff, Diana
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Protsenko, Ekate ...
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visa fler...
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Lampa, Jon
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Lee, Yvonne C.
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Hoglund, Carolin ...
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Catana, Ciprian
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Cervenka, Simon
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Akeju, Oluwaseun
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Lekander, Mats
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Cohen, George
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Halldin, Christe ...
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Taylor, Norman
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Kim, Minhae
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Hooker, Jacob M.
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Edwards, Robert ...
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Napadow, Vitaly
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Kosek, Eva
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Loggia, Marco L.
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visa färre...
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