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Cytokine expression...
Cytokine expression and lymphocyte proliferative capacity in diseased harbor porpoises (Phocoena phocoena) - Biomarkers for health assessment in wildlife cetaceans
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Lehnert, Kristina (författare)
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Siebert, Ursula (författare)
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Reissmann, Kristina (författare)
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Bruhn, Regina (författare)
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- McLachlan, Michael S. (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Baltic Sea Research Institute, Germany
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Müller, Gundi (författare)
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van Elk, Cornelis E. (författare)
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Ciurkiewicz, Malgorzata (författare)
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Baumgärtner, Wolfgang (författare)
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Beineke, Andreas (författare)
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
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Ingår i: Environmental Pollution. - : Elsevier BV. - 0269-7491 .- 1873-6424. ; 247, s. 783-791
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Harbor porpoises (Phocoena phocoena) in the North and Baltic Seas are exposed to anthropogenic influences including acoustic stress and environmental contaminants. In order to evaluate immune responses in healthy and diseased harbor porpoise cells, cytokine expression analyses and lymphocyte proliferation assays, together with toxicological analyses were performed in stranded and bycaught animals as well as in animals kept in permanent human care. Severely diseased harbor porpoises showed a reduced proliferative capacity of peripheral blood lymphocytes together with diminished transcription of transforming growth factor-beta and tumor necrosis factor-alpha compared to healthy controls. Toxicological analyses revealed accumulation of polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), and dichlorodiphenyltrichloroethane (DDT) in harbor porpoise blood samples. Correlation analyses between blood organochlorine levels and immune parameters revealed no direct effects of xenobiotics upon lymphocyte proliferation or cytokine transcription, respectively. Results reveal an impaired function of peripheral blood leukocytes in severely diseased harbor porpoises, indicating immune exhaustion and increased disease susceptibility.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
Nyckelord
- Harbor porpoise
- Blood samples
- Lymphocyte proliferation
- Mitogens
- Xenobiotics
- Cytokine expression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Lehnert, Kristin ...
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Siebert, Ursula
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Reissmann, Krist ...
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Bruhn, Regina
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McLachlan, Micha ...
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Müller, Gundi
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visa fler...
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van Elk, Corneli ...
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Ciurkiewicz, Mal ...
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Baumgärtner, Wol ...
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Beineke, Andreas
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visa färre...
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- NATURVETENSKAP
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NATURVETENSKAP
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Environmental Po ...
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Stockholms universitet