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The strength in num...
The strength in numbers : comprehensive characterization of house dust using complementary mass spectrometric techniques
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Rostkowski, Pawel (författare)
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- Haglund, Peter (författare)
- Umeå universitet,Kemiska institutionen
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Aalizadeh, Reza (författare)
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Alygizakis, Nikiforos (författare)
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Thomaidis, Nikolaos (författare)
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Beltran Arandes, Joaquin (författare)
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Nizzetto, Pernilla Bohlin (författare)
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Booij, Petra (författare)
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Budzinski, Helene (författare)
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Brunswick, Pamela (författare)
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Covaci, Adrian (författare)
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- Gallampois, Christine, 1974- (författare)
- Umeå universitet,Kemiska institutionen
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Grosse, Sylvia (författare)
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Hindle, Ralph (författare)
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Ipolyi, Ildiko (författare)
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Jobst, Karl (författare)
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Kaserzon, Sarit L. (författare)
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Leonards, Pim (författare)
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Lestremau, Francois (författare)
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Letzel, Thomas (författare)
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Magner, Jorgen (författare)
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Matsukami, Hidenori (författare)
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Moschet, Christoph (författare)
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Oswald, Peter (författare)
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- Plassmann, Merle (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
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Slobodnik, Jaroslav (författare)
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Yang, Chun (författare)
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(creator_code:org_t)
- 2019-03-04
- 2019
- Engelska.
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Ingår i: Analytical and Bioanalytical Chemistry. - : Springer Science and Business Media LLC. - 1618-2642 .- 1618-2650. ; 411:10, s. 1957-1977
- Relaterad länk:
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https://doi.org/10.1...
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https://link.springe...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Untargeted analysis of a composite house dust sample has been performed as part of a collaborative effort to evaluate the progress in the field of suspect and nontarget screening and build an extensive database of organic indoor environment contaminants. Twenty-one participants reported results that were curated by the organizers of the collaborative trial. In total, nearly 2350 compounds were identified (18%) or tentatively identified (25% at confidence level 2 and 58% at confidence level 3), making the collaborative trial a success. However, a relatively small share (37%) of all compounds were reported by more than one participant, which shows that there is plenty of room for improvement in the field of suspect and nontarget screening. An even a smaller share (5%) of the total number of compounds were detected using both liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). Thus, the two MS techniques are highly complementary. Most of the compounds were detected using LC with electrospray ionization (ESI) MS and comprehensive 2D GC (GCxGC) with atmospheric pressure chemical ionization (APCI) and electron ionization (EI), respectively. Collectively, the three techniques accounted for more than 75% of the reported compounds. Glycols, pharmaceuticals, pesticides, and various biogenic compounds dominated among the compounds reported by LC-MS participants, while hydrocarbons, hydrocarbon derivatives, and chlorinated paraffins and chlorinated biphenyls were primarily reported by GC-MS participants. Plastics additives, flavor and fragrances, and personal care products were reported by both LC-MS and GC-MS participants. It was concluded that the use of multiple analytical techniques was required for a comprehensive characterization of house dust contaminants. Further, several recommendations are given for improved suspect and nontarget screening of house dust and other indoor environment samples, including the use of open-source data processing tools. One of the tools allowed provisional identification of almost 500 compounds that had not been reported by participants.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- House dust
- Suspect and nontarget analysis
- Collaborative trial
- Complementary analytical techniques
- Mass spectrometry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Rostkowski, Pawe ...
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Haglund, Peter
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Aalizadeh, Reza
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Alygizakis, Niki ...
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Thomaidis, Nikol ...
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Beltran Arandes, ...
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visa fler...
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Nizzetto, Pernil ...
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Booij, Petra
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Budzinski, Helen ...
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Brunswick, Pamel ...
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Covaci, Adrian
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Gallampois, Chri ...
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Grosse, Sylvia
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Hindle, Ralph
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Ipolyi, Ildiko
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Jobst, Karl
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Kaserzon, Sarit ...
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Leonards, Pim
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Lestremau, Franc ...
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Letzel, Thomas
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Magner, Jorgen
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Matsukami, Hiden ...
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Moschet, Christo ...
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Oswald, Peter
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Plassmann, Merle
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Slobodnik, Jaros ...
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Yang, Chun
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Analytisk kemi
- Artiklar i publikationen
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Analytical and B ...
- Av lärosätet
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Stockholms universitet
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Umeå universitet