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General Cyclopropan...
General Cyclopropane Assembly by Enantioselective Transfer of a Redox-Active Carbene to Aliphatic Olefins
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- Montesinos-Magraner, Marc (författare)
- Stockholms universitet,Institutionen för organisk kemi
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- Costantini, Matteo (författare)
- Stockholms universitet,Institutionen för organisk kemi
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- Ramírez-Contreras, Rodrigo (författare)
- Stockholms universitet,Institutionen för organisk kemi
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Muratore, Michael E. (författare)
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Johansson, Magnus J. (författare)
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- Mendoza, Abraham (författare)
- Stockholms universitet,Institutionen för organisk kemi
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(creator_code:org_t)
- Wiley, 2019
- 2019
- Engelska.
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Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 58:18, s. 5930-5935
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https://su.diva-port... (primary) (Raw object)
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http://su.diva-porta...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Asymmetric cyclopropane synthesis currently requires bespoke strategies, methods, substrates, and reagents, even when targeting similar compounds. This approach slows down discovery and limits available chemical space. Introduced herein is a practical and versatile diazocompound and its performance in the first unified asymmetric synthesis of functionalized cyclopropanes. The redox-active leaving group in this reagent enhances the reactivity and selectivity of geminal carbene transfer. This effect allowed the asymmetric cyclopropanation of various olefins, including unfunctionalized aliphatic alkenes, that enables the three-step total synthesis of (-)-dictyoptereneA. This unified synthetic approach delivers high enantioselectivities that are independent of the stereoelectronic properties of the functional groups transferred. Our results demonstrate that orthogonally differentiated diazocompounds are viable and advantageous equivalents of single-carbon chirons.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- alkenes
- diazo compounds
- ruthenium
- small-ring compounds
- synthetic methods
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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