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Crystal structure o...
Crystal structure of the catalytic domain of the Weissella oryzae botulinum-like toxin
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- Košenina, Sara (författare)
- Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik
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- Masuyer, Geoffrey (författare)
- Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik
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- Zhang, Sicai (författare)
- Harvard Medical School
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- Dong, Min (författare)
- Harvard Medical School
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- Stenmark, Pål (författare)
- Stockholm University,Lunds universitet,Stockholms universitet,Institutionen för biokemi och biofysik,Lund University, Sweden,Strukturell biokemi,Forskargrupper vid Lunds universitet,Structural Biochemistry,Lund University Research Groups
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(creator_code:org_t)
- 2019-05-31
- 2019
- Engelska.
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Ingår i: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 593:12, s. 1403-1410
- Relaterad länk:
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https://febs.onlinel...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Botulinum neurotoxins (BoNTs) are the most potent toxins known. So far, eight serotypes have been identified that all act as zinc-dependent endopeptidases targeting SNARE proteins and inhibiting the release of neurotransmitters. Recently, the first botulinum toxin-like protein was identified outside the Clostridial genus, designated BoNT/Wo in the genome of Weissella oryzae. Here, we report the 1.6 angstrom X-ray crystal structure of the light chain of BoNT/Wo (LC/Wo). LC/Wo presents the core fold common to BoNTs but has an unusually wide, open and negatively charged catalytic pocket, with an additional Ca2+ ion besides the zinc ion and a unique ss-hairpin motif. The structural information will help establish the substrate profile of BoNT/Wo and help our understanding of how BoNT evolved.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Strukturbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Structural Biology (hsv//eng)
Nyckelord
- botulinum neurotoxin
- Weissella oryzae
- X-ray crystallography
- zinc endopeptidase
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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