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Early life exposure...
Early life exposure to phthalates in the Canadian Healthy Infant Longitudinal Development (CHILD) study : a multi-city birth cohort
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- Navaranjan, Garthika (författare)
- University of Toronto, Canada.
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- Takaro, Tim K. (författare)
- Simon Fraser University, Canada.
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- Wheeler, Amanda J. (författare)
- Australian Catholic University, Australia.;University of Tasmania, Australia.
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visa fler...
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- Diamond, Miriam L. (författare)
- University of Toronto, Canada.
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- Shu, Huan (författare)
- Karlstads universitet,Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Karlstad University, Sweden,Institutionen för hälsovetenskaper (from 2013),Stockholm University
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- Azad, Meghan B. (författare)
- University of Manitoba, Canada.
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- Becker, Allan B. (författare)
- Univ of Manitoba, Canada
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- Dai, Ruixue (författare)
- Hosp Sick Children, Canada.
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- Harris, Shelley A. (författare)
- University of Toronto, Canada.; Cancer Care Ontario, Canada.
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- Lefebvre, Diana L. (författare)
- McMaster University, Canada
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- Lu, Zihang (författare)
- Hosp Sick Children, Canada
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- Mandhane, Piush J. (författare)
- University of Alberta, Canada
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- McLean, Kathleen (författare)
- BC Ctr Dis Control, Canada
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- Moraes, Theo J. (författare)
- University of Toronto, Canada; Hosp Sick Children, Canada
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- Scott, James A. (författare)
- University of Toronto, Canada
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- Turvey, Stuart E. (författare)
- University of British Columbia, Canada
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- Sears, Malcolm R. (författare)
- McMaster University, Canada
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- Subbarao, Padmaja (författare)
- University of Toronto, Canada.; Hosp Sick Children, Canada
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- Brook, Jeffrey R. (författare)
- University of Toronto, Canada
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University of Toronto, Canada Simon Fraser University, Canada. (creator_code:org_t)
- 2019-10-22
- 2020
- Engelska.
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Ingår i: Journal of Exposure Science and Environmental Epidemiology. - : Springer Science and Business Media LLC. - 1559-0631 .- 1559-064X. ; 30:1, s. 70-85
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background Few studies have examined phthalate exposure during infancy and early life, critical windows of development. The Canadian Healthy Infant Longitudinal Development (CHILD) study, a population-based birth cohort, ascertained multiple exposures during early life. Objective To characterize exposure to phthalates during infancy and early childhood. Methods Environmental questionnaires were administered, and urine samples collected at 3, 12, and 36 months. In the first 1578 children, urine was analyzed for eight phthalate metabolites: mono-methyl phthalate (MMP), mono-ethyl phthalate (MEP), mono-butyl phthalate (MBP), mono-benzyl phthalate (MBzP), mono-2-ethylhexyl phthalate (MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono-3-carboxypropyl phthalate (MCPP). Geometric mean (GM) concentrations were calculated by age, together with factors that may influence concentrations. Trends with age were examined using mixed models and differences within factors examined using ANOVA. Results The highest urinary concentration was for the metabolite MBP at all ages (GM: 15-32 ng/mL). Concentrations of all phthalate metabolites significantly increased with age ranging from GM: 0.5-15.1 ng/mL at 3 months and 1.9-32.1 ng/mL at 36 months. Concentrations of all metabolites were higher in the lowest income categories except for MEHP at 3 months, among children with any breastfeeding at 12 months, and in urine collected on dates with warmer outdoor temperatures (>17 degrees C), except for MBzP at 3 months and MEHP at 3 and 12 months. No consistent differences were found by gender, study site, or maternal age. Conclusions Higher phthalate metabolite concentrations were observed among children in lower income families. Examination of factors associated with income could inform interventions aimed to reduce infant phthalate exposure.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- Phthalates
- Children
- Biological monitoring
- Urine
- Exposure assessment
- Socioeconomic status
- Public Health Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Navaranjan, Gart ...
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Takaro, Tim K.
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Wheeler, Amanda ...
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Diamond, Miriam ...
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Shu, Huan
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Azad, Meghan B.
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visa fler...
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Becker, Allan B.
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Dai, Ruixue
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Harris, Shelley ...
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Lefebvre, Diana ...
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Lu, Zihang
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Mandhane, Piush ...
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McLean, Kathleen
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Moraes, Theo J.
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Scott, James A.
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Turvey, Stuart E ...
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Sears, Malcolm R ...
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Subbarao, Padmaj ...
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Brook, Jeffrey R ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Geovetenskap och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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Journal of Expos ...
- Av lärosätet
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Stockholms universitet
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Karlstads universitet