Sökning: onr:"swepub:oai:DiVA.org:su-181934" > Size-Dependent Pulm...
Fältnamn | Indikatorer | Metadata |
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000 | 03712naa a2200565 4500 | |
001 | oai:DiVA.org:su-181934 | |
003 | SwePub | |
008 | 200616s2020 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:143601386 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1819342 URI |
024 | 7 | a https://doi.org/10.1002/advs.2019032002 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1436013862 URI |
040 | a (SwePub)sud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Rodrigues, Artur Filipe4 aut |
245 | 1 0 | a Size-Dependent Pulmonary Impact of Thin Graphene Oxide Sheets in Mice :b Toward Safe-by-Design |
264 | c 2020-05-07 | |
264 | 1 | b Wiley,c 2020 |
338 | a print2 rdacarrier | |
520 | a Safety assessment of graphene-based materials (GBMs) including graphene oxide (GO) is essential for their safe use across many sectors of society. In particular, the link between specific material properties and biological effects needs to be further elucidated. Here, the effects of lateral dimensions of GO sheets in acute and chronic pulmonary responses after single intranasal instillation in mice are compared. Micrometer-sized GO induces stronger pulmonary inflammation than nanometer-sized GO, despite reduced translocation to the lungs. Genome-wide RNA sequencing also reveals distinct size-dependent effects of GO, in agreement with the histopathological results. Although large GO, but not the smallest GO, triggers the formation of granulomas that persists for up to 90 days, no pulmonary fibrosis is observed. These latter results can be partly explained by Raman imaging, which evidences the progressive biotransformation of GO into less graphitic structures. The findings demonstrate that lateral dimensions play a fundamental role in the pulmonary response to GO, and suggest that airborne exposure to micrometer-sized GO should be avoided in the production plant or applications, where aerosolized dispersions are likely to occur. These results are important toward the implementation of a safer-by-design approach for GBM products and applications, for the benefit of workers and end-users. | |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
650 | 7 | a NATURVETENSKAPx Fysik0 (SwePub)1032 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Physical Sciences0 (SwePub)1032 hsv//eng |
653 | a graphene oxide | |
653 | a inflammation | |
653 | a lung | |
653 | a macrophages | |
653 | a mice | |
653 | a RNA sequencing | |
700 | 1 | a Newman, Leon4 aut |
700 | 1 | a Jasim, Dhifaf4 aut |
700 | 1 | a Mukherjee, Sourav P.4 aut |
700 | 1 | a Wang, Junu Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)juwa8232 |
700 | 1 | a Vacchi, Isabella A.4 aut |
700 | 1 | a Ménard-Moyon, Cécilia4 aut |
700 | 1 | a Bianco, Alberto4 aut |
700 | 1 | a Fadeel, Bengtu Karolinska Institutet4 aut |
700 | 1 | a Kostarelos, Kostas4 aut |
700 | 1 | a Bussy, Cyrill4 aut |
710 | 2 | a Stockholms universitetb Institutionen för biokemi och biofysik4 org |
773 | 0 | t Advanced Scienced : Wileyg 7:12q 7:12x 2198-3844 |
856 | 4 | u https://doi.org/10.1002/advs.201903200y Fulltext |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.201903200 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-181934 |
856 | 4 8 | u https://doi.org/10.1002/advs.201903200 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143601386 |
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