Sökning: onr:"swepub:oai:DiVA.org:su-191268" > Epigenetic alterati...
Fältnamn | Indikatorer | Metadata |
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000 | 04487naa a2200529 4500 | |
001 | oai:DiVA.org:su-191268 | |
003 | SwePub | |
008 | 210318s2020 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:145805558 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1912682 URI |
024 | 7 | a https://doi.org/10.1038/s41598-020-74798-z2 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1458055582 URI |
040 | a (SwePub)sud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Acevedo, Nathalie4 aut |
245 | 1 0 | a Epigenetic alterations in skin homing CD4(+)CLA(+) T cells of atopic dermatitis patients |
264 | c 2020-10-22 | |
264 | 1 | b Springer Science and Business Media LLC,c 2020 |
338 | a print2 rdacarrier | |
520 | a T cells expressing the cutaneous lymphocyte antigen (CLA) mediate pathogenic inflammation in atopic dermatitis (AD). The molecular alterations contributing to their dysregulation remain unclear. With the aim to elucidate putative altered pathways in AD we profiled DNA methylation levels and miRNA expression in sorted T cell populations -(CD4(+), -CD4(+)CD45RA(+) naive, -CD4(+)CLA(+), and -CD8(+)) from adult AD patients and healthy controls (HC). Skin homing -CD4(+)CLA(+) T cells from AD patients showed significant differences in DNA methylation in 40 genes compared to HC (p < 0.05). Reduced DNA methylation levels in the upstream region of the interleukin-13 gene (IL13) in -CD4(+)CLA(+) T cells from AD patients correlated with increased IL13 mRNA expression in these cells. Sixteen miRNAs showed differential expression in -CD4(+)CLA(+) T cells from AD patients targeting genes in 202 biological processes (p < 0.05). An integrated network analysis of miRNAs and CpG sites identified two communities of strongly interconnected regulatory elements with strong antagonistic behaviours that recapitulated the differences between AD patients and HC. Functional analysis of the genes linked to these communities revealed their association with key cytokine signaling pathways, MAP kinase signaling and protein ubiquitination. Our findings support that epigenetic mechanisms play a role in the pathogenesis of AD by affecting inflammatory signaling molecules in skin homing -CD4(+)CLA(+) T cells and uncover putative molecules participating in AD pathways. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Benfeitas, Ruiu Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)rube5211 |
700 | 1 | a Katayama, Shintarou Karolinska Institutet4 aut |
700 | 1 | a Bruhn, Sören4 aut |
700 | 1 | a Andersson, Annau Karolinska Institutet4 aut |
700 | 1 | a Wikberg, Gustav4 aut |
700 | 1 | a Lundeberg, Lena4 aut |
700 | 1 | a Lindvall, Jessica M.u Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)jeli1689 |
700 | 1 | a Greco, Dario4 aut |
700 | 1 | a Kere, Juhau Karolinska Institutet4 aut |
700 | 1 | a Söderhäll, Cillau Karolinska Institutet4 aut |
700 | 1 | a Scheynius, Annika4 aut |
710 | 2 | a Stockholms universitetb Institutionen för biokemi och biofysik4 org |
773 | 0 | t Scientific Reportsd : Springer Science and Business Media LLCg 10:1q 10:1x 2045-2322 |
856 | 4 | u https://doi.org/10.1038/s41598-020-74798-zy Fulltext |
856 | 4 | u https://www.nature.com/articles/s41598-020-74798-z.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-191268 |
856 | 4 8 | u https://doi.org/10.1038/s41598-020-74798-z |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145805558 |
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