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Acetylcholinesteras...
Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer's Disease Therapy
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- Arya, Ashwani (författare)
- Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak 124001, Haryana, India.,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.
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- Chahal, Rubal (författare)
- Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak 124001, Haryana, India.
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- Rao, Rekha (författare)
- Guru Jambeshwar Univ Sci & Technol, Dept Pharmaceut Sci, Hisar 125001, Haryana, India.
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- Rahman, Md. Habibur (författare)
- Southeast Univ, Dept Pharm, Dhaka 1213, Bangladesh.;Yonsei Univ, Wonju Coll Med, Dept Global Med Sci, Wonju 26384, South Korea.
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- Kaushik, Deepak (författare)
- Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak 124001, Haryana, India.
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- Akhtar, Muhammad Furqan (författare)
- Riphah Int Univ, Riphah Inst Pharmaceut Sci, Lahore Campus, Lahore 54000, Pakistan.
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- Saleem, Ammara (författare)
- Govt Coll Univ Faisalabad, Fac Pharmaceut Sci, Dept Pharmacol, Faisalabad 38000, Pakistan.
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- Khalifa, Shaden A. M. (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Farmakognosi,Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.;Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt.
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- Kamel, Mohamed (författare)
- Cairo Univ, Dept Med & Infect Dis, Fac Vet Med, Giza 12211, Egypt.
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- Albadrani, Ghadeer M. (författare)
- Princess Nourah bint Abdulrahman Univ, Dept Biol, Coll Sci, Riyadh 11474, Saudi Arabia.
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- Abdel-Daim, Mohamed M. (författare)
- Suez Canal Univ, Fac Vet Med, Pharmacol Dept, Ismailia 41522, Egypt.
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- Mittal, Vineet (författare)
- Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak 124001, Haryana, India.
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Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak 124001, Haryana, India Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden. (creator_code:org_t)
- 2021-02-25
- 2021
- Engelska.
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Ingår i: Biomolecules. - : MDPI AG. - 2218-273X. ; 11:3
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Alzheimer’s disease (AD) is a gradually growing irreversible illness of the brain that almost affects every fifth person (aged > 80 years) in the world. World Health Organization (WHO) also revealed that the prevalence of this disease will enhance (upto double) significantly upto 2030. The poor cholinergic transmission at the synapse is considered to be one of the main reasons behind the progression and occurrence of this disorder. Natural inhibitors of acetylcholine (ACh) such as galanthamine and rivastigmine are used commercially in the treatmentof AD. The biomolecules such assesquiterpenes, possess a great structural diversity and are responsible for a plethora of pharmacological properties. The potential of various sesquiterpenes as anticholinesterase has been reviewed in this article. For this purpose, the various databases, mainly PubMed, Scopus, and Web of Science were investigatedwith different keywords such as “sesquiterpenes+acetylcholinesterase” and “sesquiterpenes+cholinesterase+inhibitors” in the surveyed time frame (2010–2020). A vast literature was evident in the last decade, which affirms the potential of various sesquiterpenes in the improvement of cholinergic transmission by inhibiting the AChE. After data analysis, it was found that 12 compounds out of a total of 58 sesquiterpenes were reported to possess IC50 < 9 μM and can be considered as potential candidates for the improvement of learning and memory. Sesquiterpene is an important category of terpenoids, found to possess a large spectrum of biological activities. The outcome of the review clearly states that sesquiterpenes (such as amberboin, lipidiol, etc.) from herbs could offer fresh, functional compounds for possible prevention and treatment of AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- cognition
- coumarins
- lactones
- phytochemicals
- neurodegeneration
- acetylcholinesterase
- Alzheimer's disease
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Till lärosätets databas
- Av författaren/redakt...
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Arya, Ashwani
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Chahal, Rubal
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Rao, Rekha
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Rahman, Md. Habi ...
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Kaushik, Deepak
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Akhtar, Muhammad ...
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Saleem, Ammara
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Khalifa, Shaden ...
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El-Seedi, Hesham
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Kamel, Mohamed
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Albadrani, Ghade ...
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Abdel-Daim, Moha ...
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Mittal, Vineet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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- Artiklar i publikationen
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Biomolecules
- Av lärosätet
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Stockholms universitet
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Uppsala universitet