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Unboxing mutations :
Unboxing mutations : Connecting mutation types with evolutionary consequences
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- Berdan, Emma L. (författare)
- Stockholms universitet,Institutionen för ekologi, miljö och botanik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Sci Life Lab, Dept Ecol Environm & Plant Sci, SE-10691 Stockholm, Sweden.
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- Blanckaert, Alexandre (författare)
- Univ Wisconsin, Lab Genet, Madison, WI 53706 USA.
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- Slotte, Tanja (författare)
- Stockholms universitet,Institutionen för ekologi, miljö och botanik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Sci Life Lab, Dept Ecol Environm & Plant Sci, SE-10691 Stockholm, Sweden.
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- Suh, Alexander (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Systematisk biologi,Univ East Anglia, Sch Biol Sci Organisms & Environm, Norwich, Norfolk, England.
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- Westram, Anja M. (författare)
- IST Austria, Klosterneuburg, Austria.;Nord Univ, Fac Biosci & Aquaculture, Bodo, Norway.
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- Fragata, Inês (författare)
- Univ Lisbon, Fac Ciencias, cE3c Ctr Ecol Evolut & Environm Changes, Lisbon, Portugal.
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(creator_code:org_t)
- 2021-05-19
- 2021
- Engelska.
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Ingår i: Molecular Ecology. - : Wiley. - 0962-1083 .- 1365-294X. ; 30:12, s. 2710-2723
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- A key step in understanding the genetic basis of different evolutionary outcomes (e.g., adaptation) is to determine the roles played by different mutation types (e.g., SNPs, translocations and inversions). To do this we must simultaneously consider different mutation types in an evolutionary framework. Here, we propose a research framework that directly utilizes the most important characteristics of mutations, their population genetic effects, to determine their relative evolutionary significance in a given scenario. We review known population genetic effects of different mutation types and show how these may be connected to different evolutionary outcomes. We provide examples of how to implement this framework and pinpoint areas where more data, theory and synthesis are needed. Linking experimental and theoretical approaches to examine different mutation types simultaneously is a critical step towards understanding their evolutionary significance.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Nyckelord
- adaptation
- distribution of fitness effects
- mutation
- mutation rate
- population genetics
- recombination
- speciation
- structural variant
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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