Sökning: onr:"swepub:oai:DiVA.org:su-197505" >
Anti-Viral and Immu...
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Yosri, NermeenJiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.;Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
(författare)
Anti-Viral and Immunomodulatory Properties of Propolis : Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-07-31
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MDPI AG,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:su-197505
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-197505URI
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https://doi.org/10.3390/foods10081776DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-455460URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:for swepub-publicationtype
Anmärkningar
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Propolis, a resin produced by honeybees, has long been used as a dietary supplement and folk remedy, and more recent preclinical investigations have demonstrated a large spectrum of potential therapeutic bioactivities, including antioxidant, antibacterial, anti-inflammatory, neuroprotective, immunomodulatory, anticancer, and antiviral properties. As an antiviral agent, propolis and various constituents have shown promising preclinical efficacy against adenoviruses, influenza viruses, respiratory tract viruses, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), human immunodeficiency virus (HIV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 300 chemical components have been identified in propolis, including terpenes, flavonoids, and phenolic acids, with the specific constituent profile varying widely according to geographic origin and regional flora. Propolis and its constituents have demonstrated potential efficacy against SARS-CoV-2 by modulating multiple pathogenic and antiviral pathways. Molecular docking studies have demonstrated high binding affinities of propolis derivatives to multiple SARS-CoV-2 proteins, including 3C-like protease (3CL(pro)), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp), the receptor-binding domain (RBD) of the spike protein (S-protein), and helicase (NSP13), as well as to the viral target angiotensin-converting enzyme 2 (ACE2). Among these compounds, retusapurpurin A has shown high affinity to 3CL(pro) (Delta G = -9.4 kcal/mol), RdRp (-7.5), RBD (-7.2), NSP13 (-9.4), and ACE2 (-10.4) and potent inhibition of viral entry by forming hydrogen bonds with amino acid residues within viral and human target proteins. In addition, propolis-derived baccharin demonstrated even higher binding affinity towards PLpro (-8.2 kcal/mol). Measures of drug-likeness parameters, including metabolism, distribution, absorption, excretion, and toxicity (ADMET) characteristics, also support the potential of propolis as an effective agent to combat COVID-19.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Abd El-Wahed, Aida A.Agr Res Ctr, Plant Protect Res Inst, Dept Bee Res, Giza 12627, Egypt.
(författare)
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Ghonaim, ReemMenoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
(författare)
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Khattab, Omar M.Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
(författare)
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Sabry, AyaMenoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
(författare)
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Ibrahim, Mahmoud A. A.Minia Univ, Fac Sci, Chem Dept, Computat Chem Lab, Al Minya 61519, Egypt.
(författare)
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Moustafa, Mahmoud F.King Khalid Univ, Coll Sci, Dept Biol, Abha 9004, Saudi Arabia.;South Valley Univ, Fac Sci, Dept Bot & Microbiol, Qena 83523, Egypt.,Alnahalaljwal Fdn Saudi Arabia, POB 617, Al Jumum 21926, Saudi Arabia.
(författare)
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Guo, ZhimingJiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.
(författare)
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Zou, XiaoboJiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.
(författare)
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Algethami, Ahmed F. M.
(författare)
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Masry, Saad H. D.City Sci Res & Technol Applicat, Dept Plant Protect & Biomol Diag, Arid Lands Cultivat Res Inst ALCRI, Alexandria 21934, Egypt.;Abu Dhabi Agr & Food Safety Author ADAFSA, Al Ain 52150, U Arab Emirates.
(författare)
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AlAjmi, Mohamed F.King Saud Univ, Coll Pharm, Pharmacognosy Grp, Riyadh 11451, Saudi Arabia.
(författare)
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Afifi, Hanan S.Abu Dhabi Agr & Food Safety Author ADAFSA, R&D Div, Food Res Sect, POB 52150, Abu Dhabi, U Arab Emirates.
(författare)
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Khalifa, Shaden A. M.Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, SE-10691 Stockholm, Sweden.(Swepub:su)shkha
(författare)
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El-Seedi, Hesham R.Uppsala universitet,Farmakognosi,Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.;Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.(Swepub:uu)heels173
(författare)
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Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.;Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.Agr Res Ctr, Plant Protect Res Inst, Dept Bee Res, Giza 12627, Egypt.
(creator_code:org_t)
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Ingår i:Foods: MDPI AG10:82304-8158
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Yosri, Nermeen
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Abd El-Wahed, Ai ...
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Ghonaim, Reem
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Khattab, Omar M.
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Sabry, Aya
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Ibrahim, Mahmoud ...
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Moustafa, Mahmou ...
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Guo, Zhiming
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Zou, Xiaobo
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Algethami, Ahmed ...
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Masry, Saad H. D ...
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AlAjmi, Mohamed ...
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Afifi, Hanan S.
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