Sökning: onr:"swepub:oai:DiVA.org:su-198401" > Ten Years of Collab...
Fältnamn | Indikatorer | Metadata |
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000 | 03517naa a2200529 4500 | |
001 | oai:DiVA.org:su-198401 | |
003 | SwePub | |
008 | 211111s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1984012 URI |
024 | 7 | a https://doi.org/10.1093/molbev/msab0982 DOI |
040 | a (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a for2 swepub-publicationtype |
100 | 1 | a Linard, Benjamin4 aut |
245 | 1 0 | a Ten Years of Collaborative Progress in the Quest for Orthologs |
264 | c 2021-04-02 | |
264 | 1 | b Oxford University Press (OUP),c 2021 |
338 | a print2 rdacarrier | |
520 | a Accurate determination of the evolutionary relationships between genes is a foundational challenge in biology. Homology-evolutionary relatedness-is in many cases readily determined based on sequence similarity analysis. By contrast, whether or not two genes directly descended from a common ancestor by a speciation event (orthologs) or duplication event (paralogs) is more challenging, yet provides critical information on the history of a gene. Since 2009, this task has been the focus of the Quest for Orthologs (QFO) Consortium. The sixth QFO meeting took place in Okazaki, Japan in conjunction with the 67th National Institute for Basic Biology conference. Here, we report recent advances, applications, and oncoming challenges that were discussed during the conference. Steady progress has been made toward standardization and scalability of new and existing tools. A feature of the conference was the presentation of a panel of accessible tools for phylogenetic profiling and several developments to bring orthology beyond the gene unit-from domains to networks. This meeting brought into light several challenges to come: leveraging orthology computations to get the most of the incoming avalanche of genomic data, integrating orthology from domain to biological network levels, building better gene models, and adapting orthology approaches to the broad evolutionary and genomic diversity recognized in different forms of life and viruses. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
653 | a orthology | |
653 | a viruses | |
653 | a phylogenetic profiling | |
653 | a paralogy | |
653 | a xenology | |
653 | a gene models | |
700 | 1 | a Ebersberger, Ingo4 aut |
700 | 1 | a McGlynn, Shawn E.4 aut |
700 | 1 | a Glover, Natasha4 aut |
700 | 1 | a Mochizuki, Tomohiro4 aut |
700 | 1 | a Patricio, Mateus4 aut |
700 | 1 | a Lecompte, Odile4 aut |
700 | 1 | a Nevers, Yannis4 aut |
700 | 1 | a Thomas, Paul D.4 aut |
700 | 1 | a Gabaldon, Toni4 aut |
700 | 1 | a Sonnhammer, Eriku Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för biokemi och biofysik4 aut0 (Swepub:su)esonn |
700 | 1 | a Dessimoz, Christophe4 aut |
700 | 1 | a Uchiyama, Ikuo4 aut |
710 | 2 | a Stockholms universitetb Science for Life Laboratory (SciLifeLab)4 org |
773 | 0 | t Molecular biology and evolutiond : Oxford University Press (OUP)g 38:8, s. 3033-3045q 38:8<3033-3045x 0737-4038x 1537-1719 |
856 | 4 | u https://doi.org/10.1093/molbev/msab098y Fulltext |
856 | 4 | u https://academic.oup.com/mbe/article-pdf/38/8/3033/39457256/msab098.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-198401 |
856 | 4 8 | u https://doi.org/10.1093/molbev/msab098 |
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