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An essential functi...
An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea
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Yin, Wenguang (författare)
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- Liontos, Andreas (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab)
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Koepke, Janine (författare)
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Ghoul, Maroua (författare)
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Mazzocchi, Luciana (författare)
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Liu, Xinyuan (författare)
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Lu, Chunyan (författare)
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Wu, Haoyu (författare)
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Fysikopoulos, Athanasios (författare)
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- Sountoulidis, Alex (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab)
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Seeger, Werner (författare)
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Ruppert, Clemens (författare)
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Gunther, Andreas (författare)
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Stainier, Didier Y. R. (författare)
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- Samakovlis, Christos (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab),Justus Liebig University of Giessen, Germany; Max Planck Institute for Heart and Lung Research, Germany
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(creator_code:org_t)
- 2022-02-07
- 2022
- Engelska.
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Ingår i: Development. - : The Company of Biologists. - 0950-1991 .- 1477-9129. ; 149:3
- Relaterad länk:
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https://doi.org/10.1...
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https://journals.bio...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The tracheal epithelium is a primary target for pulmonary diseases as it provides a conduit for air flow between the environment and the lung lobes. The cellular and molecular mechanisms underlying airway epithelial cell proliferation and differentiation remain poorly understood. Hedgehog (HH) signaling orchestrates communication between epithelial and mesenchymal cells in the lung, where it modulates stromal cell proliferation, differentiation and signaling back to the epithelium. Here, we reveal a previously unreported autocrine function of HH signaling in airway epithelial cells. Epithelial cell depletion of the ligand sonic hedgehog (SHH) or its effector smoothened (SMO) causes defects in both epithelial cell proliferation and differentiation. In cultured primary human airway epithelial cells, HH signaling inhibition also hampers cell proliferation and differentiation. Epithelial HH function is mediated, at least in part, through transcriptional activation, as HH signaling inhibition leads to downregulation of cell type-specific transcription factor genes in both the mouse trachea and human airway epithelial cells. These results provide new insights into the role of HH signaling in epithelial cell proliferation and differentiation during airway development.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Sonic hedgehog
- Smoothened
- Trachea
- Tracheomalacia
- Airway epithelial cells
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Yin, Wenguang
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Liontos, Andreas
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Koepke, Janine
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Ghoul, Maroua
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Mazzocchi, Lucia ...
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Liu, Xinyuan
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visa fler...
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Lu, Chunyan
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Wu, Haoyu
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Fysikopoulos, At ...
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Sountoulidis, Al ...
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Seeger, Werner
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Ruppert, Clemens
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Gunther, Andreas
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Stainier, Didier ...
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Samakovlis, Chri ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
- Artiklar i publikationen
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Development
- Av lärosätet
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Stockholms universitet