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Plasmodium falcipar...
Plasmodium falciparum-Specific Memory B-Cell and Antibody Responses Are Associated With Immunity in Children Living in an Endemic Area of Kenya
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Jahnmatz, Peter (författare)
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Nyabundi, Diana (författare)
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- Sundling, Christopher (författare)
- Karolinska Institutet
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- Widman, Linnea (författare)
- Karolinska Institutet
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Mwacharo, Jedidah (författare)
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Musyoki, Jennifer (författare)
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Otieno, Edward (författare)
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- Ahlborg, Niklas (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Mabtech AB, Sweden
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Bejon, Philip (författare)
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Ndungu, Francis M. (författare)
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- Färnert, Anna (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-03-09
- 2022
- Engelska.
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Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 13
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Identifying the mechanism of naturally acquired immunity against Plasmodium falciparum malaria could contribute to the design of effective malaria vaccines. Using a recently developed multiplexed FluoroSpot assay, we assessed cross-sectional pre-existing memory B-cells (MBCs) and antibody responses against six well known P. falciparum antigens (MSP-119, MSP-2 (3D7), MSP-2 (FC27), MSP-3, AMA-1 and CSP) and measured their associations with previous infections and time to clinical malaria in the ensuing malaria season in Kenyan children. These children were under active weekly surveillance for malaria as part of a long-term longitudinal malaria immunology cohort study, where they are recruited from birth. After performing Cox regression analysis, we found that children with a breadth of three or more antigen-specific MBC or antibody responses at the baseline had a reduced risk for malaria in the ensuing P. falciparum transmission season. Specifically, MBC responses against AMA-1, MSP-2 (3D7) and MSP-3, as well as antibody responses to MSP-2 (3D7) and MSP-3 were prospectively associated with a reduced risk for malaria. The magnitude or breadth of MBC responses were however not correlated with the cumulative number of malaria episodes since birth. We conclude that increased breadth for merozoite antigen-specific MBC and antibody responses is associated with protection against malaria.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- P
- falciparum malaria
- recombinant antigens
- memory B-cells
- antibodies
- FluoroSpot
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Jahnmatz, Peter
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Nyabundi, Diana
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Sundling, Christ ...
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Widman, Linnea
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Mwacharo, Jedida ...
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Musyoki, Jennife ...
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visa fler...
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Otieno, Edward
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Ahlborg, Niklas
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Bejon, Philip
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Ndungu, Francis ...
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Färnert, Anna
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Immunologi inom ...
- Artiklar i publikationen
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Frontiers in Imm ...
- Av lärosätet
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Stockholms universitet
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Karolinska Institutet