Sökning: onr:"swepub:oai:DiVA.org:su-20685" > Co-transduction of ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03070naa a2200457 4500 | |
001 | oai:DiVA.org:su-20685 | |
003 | SwePub | |
008 | 080304s2008 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-206852 URI |
024 | 7 | a https://doi.org/10.1007/s10989-007-9114-z2 DOI |
040 | a (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Järver, Peteru Stockholms universitet,Institutionen för neurokemi,University of Tartu, Estonia4 aut0 (Swepub:su)pjr |
245 | 1 0 | a Co-transduction of Sleeping Beauty Transposase and Donor Plasmid via a Cell-penetrating Peptide :b A simple one-step method |
264 | c 2007-09-08 | |
264 | 1 | b Springer Science and Business Media LLC,c 2008 |
338 | a print2 rdacarrier | |
520 | a Transposable elements have emerged as a promising candidate for human non-viral gene-therapy. The Tc1/mariner transposon Sleeping Beauty is to date one of the most efficient transposons in mammals. Sleeping Beauty transposase has so far mostly been delivered to cells via a DNA source. This might cause spontaneous integration of the transposase gene and cause fatal damage to the affected cell. Hence, it would be advantageous to employ a non-genetic source for the transposase. We here show that a novel Cell-penetrating peptide, M918, has the ability to facilitate cellular delivery of both the transposase Sleeping Beauty as a protein and a transposon donor-plasmid carrying an antibiotic resistance gene in vitro. The technique is a simple and straightforward one-step method that might render a safe and efficient delivery platform for Sleeping Beauty mediated gene therapy. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
653 | a Cell-penetrating peptides | |
653 | a Protein delivery | |
653 | a Transfection | |
653 | a Transposons | |
653 | a Chemistry | |
653 | a Kemi | |
653 | a neurokemi med molekylär neurobiologi | |
653 | a Neurochemistry with Molecular Neurobiology | |
700 | 1 | a Fernaeus, Sandrau Stockholms universitet,Institutionen för neurokemi4 aut |
700 | 1 | a EL Andaloussi, Samiru Stockholms universitet,Institutionen för neurokemi4 aut |
700 | 1 | a Tjörnhammar, Marie-Louiseu Stockholms universitet,Institutionen för neurokemi4 aut0 (Swepub:su)mtj |
700 | 1 | a Langel, Ülou Stockholms universitet,Institutionen för neurokemi4 aut0 (Swepub:su)ulo |
710 | 2 | a Stockholms universitetb Institutionen för neurokemi4 org |
773 | 0 | t International journal of peptide research and therapeuticsd : Springer Science and Business Media LLCg 14:1, s. 58-63q 14:1<58-63x 1573-3904x 1573-3149 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-20685 |
856 | 4 8 | u https://doi.org/10.1007/s10989-007-9114-z |
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