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Associations of sle...
Associations of sleep timing and time in bed with dementia and cognitive decline among Chinese older adults : A cohort study
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Liu, Rui (författare)
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Ren, Yifei (författare)
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Hou, Tingting (författare)
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Liang, Xiaoyan (författare)
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Dong, Yi (författare)
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Wang, Yongxiang (författare)
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Cong, Lin (författare)
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Wang, Xiang (författare)
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Qin, Yu (författare)
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Ren, Juan (författare)
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- Sindi, Shireen (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Sweden; Imperial College London, UK
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Tang, Shi (författare)
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Du, Yifeng (författare)
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- Qiu, Chengxuan (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong University, People's Republic of China; Shandong First Medical University, People's Republic of China
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(creator_code:org_t)
- 2022-09-21
- 2022
- Engelska.
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Ingår i: Journal of The American Geriatrics Society. - : Wiley. - 0002-8614 .- 1532-5415. ; 70:11, s. 3138-3151
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Background: The longitudinal associations of sleep timing and time in bed (TIB) with dementia and cognitive decline in older adults are unclear.Methods: This population-based cohort study used data from 1982 participants who were aged >= 60 years, free of dementia, and living in rural communities in western Shandong, China. At the baseline (2014) and follow-up (2018) examinations, sleep parameters were assessed using standard questionnaires. Cognitive function was measured using the Mini-Mental State Examination (MMSE). Dementia was diagnosed following the DSM-IV criteria, and the NIA-AA criteria for Alzheimer disease (AD). Data were analyzed using restricted cubic splines, Cox proportional-hazards models, and general linear models.Results: During the mean follow-up of 3.7 years, dementia was diagnosed in 97 participants (68 with AD). Restricted cubic spline curves showed J-shaped associations of sleep duration, TIB, and rise time with dementia risk, and a reverse J-shaped association with mid-sleep time. When sleep parameters were categorized into tertiles, the multivariable-adjusted hazard ratio (HR) of incident dementia was 1.69 (95%CI 1.01-2.83) for baseline sleep duration >8 hours (vs. 7-8 h), 2.17 (1.22-3.87) for bedtime before 9 p.m. (vs. 10 p.m. or later), and 2.00 (1.23-3.24) for mid-sleep time before 1 a.m. (vs. 1-1.5 a.m.). Early bedtime and mid-sleep time were significantly associated with incident AD (HR range: 2.25-2.51; p < 0.05). Among individuals who were free of dementia at follow-up, baseline long TIB, early bedtime and mid-sleep time, early and late rise time, and prolonged TIB and advanced bedtime and mid-sleep time from baseline to follow-up were associated with a greater decline in MMSE score (p < 0.05). These associations with cognitive decline were statistically evident mainly among men or participants who were aged 60-74 years.Conclusions: Long TIB and early sleep timing are associated with an increased risk of dementia, and the associations with greater cognitive decline are evident only among older people aged 60-74 years and men.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- Alzheimer disease
- cognitive function
- dementia
- population-based cohort study
- sleep
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Liu, Rui
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Ren, Yifei
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Hou, Tingting
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Liang, Xiaoyan
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Dong, Yi
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Wang, Yongxiang
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visa fler...
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Cong, Lin
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Wang, Xiang
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Qin, Yu
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Ren, Juan
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Sindi, Shireen
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Tang, Shi
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Du, Yifeng
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Qiu, Chengxuan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Geriatrik
- Artiklar i publikationen
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Journal of The A ...
- Av lärosätet
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Stockholms universitet
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Karolinska Institutet