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In Vitro Induction ...
In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells : The Role of Anastatica hierochuntica Methanolic Extract
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- El-Garawani, Islam M. (författare)
- Menoufia Univ, Fac Sci, Dept Zool, Shibin Al Kawm 32512, Egypt.
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- Abd El-Gaber, Amira S. (författare)
- Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.,Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
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- Algamdi, Noura A. (författare)
- Taibah Univ, Fac Sci, Bot Dept, Al Madinah 42353, Saudi Arabia.
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Saeed, Aamer (författare)
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- Zhao, Chao (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China.
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- Khattab, Omar M. (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.,Farmakognosi
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- AlAjmi, Mohamed F. (författare)
- King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia.
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- Guo, Zhiming (författare)
- Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.
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- Khalifa, Shaden A. M. (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, SE-10691 Stockholm, Sweden.
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.;Jiangsu Univ, Jiangsu Educ Dept, Int Joint Res Lab Intelligent Agr & Agriprod Proc, Nanjing 210024, Peoples R China.;Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.,Farmakognosi
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Menoufia Univ, Fac Sci, Dept Zool, Shibin Al Kawm 32512, Egypt Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt. (creator_code:org_t)
- 2022-09-17
- 2022
- Engelska.
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Ingår i: Metabolites. - : MDPI AG. - 2218-1989 .- 2218-1989. ; 12:9
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Anastatica hierochuntica L. (Cruciferae) has been known in Egyptian folk medicine as a remedy for gastrointestinal disorders, diabetes and heart diseases. Despite the wide usage, A. hierochuntica research provides insufficient data to support its traditional practice. The cytotoxicity of A. hierochuntica methanolic extract was investigated on acute myeloid leukemia blasts (AML) and normal human peripheral leucocytes (NHPL). The phytochemical identification of bioactive compounds using 1H-NMR and LC-ESI-MS was also performed. A. hierochuntica extract caused non-significant cytotoxicity on NHPL, while the cytotoxicity on AML was significant (IC50: 0.38 ± 0.02 μg/mL). The negative expression of p53, upregulation of Caspase-3 and increase in the BAX/BCL-2 ratio were reported at the protein and mRNA levels. The results suggest that A. hierochuntica extract induced AML cell death via the p53-independent mitochondrial intrinsic pathway and further attention should be paid to this plant as a promising natural anticancer agent.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- acute myeloid leukemia blasts
- anticancer
- H-1-NMR
- LC-ESI-MS
- Brassicaceae
- molecular networking
- metabolites
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El-Garawani, Isl ...
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Abd El-Gaber, Am ...
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Algamdi, Noura A ...
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Saeed, Aamer
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Zhao, Chao
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Khattab, Omar M.
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AlAjmi, Mohamed ...
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Guo, Zhiming
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Khalifa, Shaden ...
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El-Seedi, Hesham
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- NATURVETENSKAP
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Metabolites
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Stockholms universitet
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