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Serum Fc-Mediated M...
Serum Fc-Mediated Monocyte Phagocytosis Activity Is Stable for Several Months after SARS-CoV-2 Asymptomatic and Mildly Symptomatic Infection
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- Vangeti, Sindhu, 1989- (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Icahn School of Medicine at Mount Sinai, USA
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Periasamy, Sivakumar (författare)
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Sun, Peifang (författare)
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Balinsky, Corey A. (författare)
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Mahajan, Avinash S. (författare)
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Kuzmina, Natalia A. (författare)
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Soares-Schanoski, Alessandra (författare)
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Cooper, Elizabeth (författare)
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Beckett, Charmagne (författare)
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Marayag, Jan (författare)
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Marrone, Amethyst (författare)
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Nunez, Edgar (författare)
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Ge, Yongchao (författare)
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Porter, Chad K. (författare)
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Goforth, Carl W. (författare)
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Lizewski, Stephen E. (författare)
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Lizewski, Rhonda (författare)
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Jani, Vihasi (författare)
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Sugiharto, Victor A. (författare)
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Schilling, Megan (författare)
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Yu, Xuechen B. (författare)
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Marjanovic, Nada (författare)
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George, Mary Catherine (författare)
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Bukreyev, Alexander (författare)
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Sealfon, Stuart C. (författare)
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Letizia, Andrew G. (författare)
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Ramos, Irene (författare)
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(creator_code:org_t)
- American Society for Microbiology, 2022
- 2022
- Engelska.
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Ingår i: Microbiology Spectrum. - : American Society for Microbiology. - 2165-0497. ; 10:6
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We investigated the temporal profile of multiple components of the serological response after asymptomatic or mildly symptomatic SARS-CoV-2 infection, in a cohort of 67 previously SARS-CoV-2 naive young adults, up to 8.5 months after infection. We found a significant decrease of spike IgG and neutralization antibody titers from early (11 to 56 days) to late (4 to 8.5 months) time points postinfection. Over the study period, S1-specific IgG levels declined significantly faster than that of the S2-specific IgG. Further, serum antibodies from PCR-confirmed participants cross-recognized S2, but not S1, of the betacoronaviruses HKU1 and OC43, suggesting a greater degree of cross-reactivity of S2 among betacoronaviruses. Antibody-Dependent Natural Killer cell Activation (ADNKA) was detected at the early time point but significantly decreased at the late time point. Induction of serum Antibody-Dependent Monocyte Phagocytosis (ADMP) was detected in all the infected participants, and its levels remained stable over time. Additionally, a reduced percentage of participants had detectable neutralizing activity against the Beta (50%), Gamma (61 to 67%), and Delta (90 to 94%) variants, both early and late postinfection, compared to the ancestral strain (100%). Antibody binding to S1 and RBD of Beta, Gamma, Delta (1.7 to 2.3-fold decrease), and Omicron (10 to 16-fold decrease) variants was also significantly reduced compared to the ancestral SARS-CoV-2 strain. Overall, we found variable temporal profiles of specific components and functionality of the serological response to SARS-CoV-2 in young adults, which is characterized by lasting, but decreased, neutralizing activity and antibody binding to S1, stable ADMP activity, and relatively stable S2-specific IgG levels.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- SARS-CoV-2
- COVID-19
- infection
- antibodies
- neutralization
- Fc-mediated functions
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Vangeti, Sindhu, ...
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Periasamy, Sivak ...
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Sun, Peifang
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Balinsky, Corey ...
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Mahajan, Avinash ...
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Kuzmina, Natalia ...
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visa fler...
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Soares-Schanoski ...
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Cooper, Elizabet ...
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Beckett, Charmag ...
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Marayag, Jan
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Marrone, Amethys ...
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Nunez, Edgar
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Ge, Yongchao
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Porter, Chad K.
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Goforth, Carl W.
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Lizewski, Stephe ...
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Lizewski, Rhonda
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Jani, Vihasi
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Sugiharto, Victo ...
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Schilling, Megan
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Yu, Xuechen B.
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Marjanovic, Nada
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George, Mary Cat ...
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Bukreyev, Alexan ...
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Sealfon, Stuart ...
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Letizia, Andrew ...
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Ramos, Irene
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Immunologi inom ...
- Artiklar i publikationen
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Microbiology Spe ...
- Av lärosätet
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Stockholms universitet