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Single-Cell Transcr...
Single-Cell Transcriptomics To Define Plasmodium falciparum Stage Transition in the Mosquito Midgut
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- Mohammed, Mubasher, Msc (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
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- Dziedziech, Alexis, 1991- (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
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- Sekar, Vaishnovi (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab),Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Sci Life Lab, Stockholm, Sweden.
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- Ernest, Medard (författare)
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, Rockville, United States,NIH, Natl Inst Allergy & Infect Dis, Lab Malaria & Vector Res, Rockville, MD 20892 USA.
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- Alves E Silva, Thiago Luiz (författare)
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, Rockville, United States,NIH, Natl Inst Allergy & Infect Dis, Lab Malaria & Vector Res, Rockville, MD 20892 USA.
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- Balan, Balu (författare)
- Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, VIC, Melbourne, Australia; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, VIC, Parkville, Australia,Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia.;Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic, Australia.
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- Emami, S. Noushin (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
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- Biryukova, Inna (författare)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Sci Life Lab, Stockholm, Sweden.
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- Friedländer, Marc R. (författare)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Sci Life Lab, Stockholm, Sweden.
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- Jex, Aaron (författare)
- Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, VIC, Melbourne, Australia; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, VIC, Parkville, Australia,Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia.;Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic, Australia.
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- Jacobs-Lorena, Marcelo (författare)
- Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, MD, Baltimore, United States,Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA.
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- Henriksson, Johan (författare)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Univ, Dept Mol Biol, Lab Mol Infect Med Sweden MIMS, Umeå, Sweden.
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- Vega-Rodriguez, Joel (författare)
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, Rockville, United States,NIH, Natl Inst Allergy & Infect Dis, Lab Malaria & Vector Res, Rockville, MD 20892 USA.
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- Ankarklev, Johan (författare)
- Uppsala universitet,Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; Microbial Single Cell Genomics, Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden,Science for Life Laboratory, SciLifeLab,Molekylär evolution,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden
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(creator_code:org_t)
- 2023-02-27
- 2023
- Engelska.
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Ingår i: Microbiology Spectrum. - : American Society for Microbiology. - 2165-0497. ; 11:2
- Relaterad länk:
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https://doi.org/10.1...
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https://su.diva-port... (primary) (Raw object)
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https://su.diva-port...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Malaria inflicts the highest rate of morbidity and mortality among the vector-borne diseases. The dramatic bottleneck of parasite numbers that occurs in the gut of the obligatory mosquito vector provides a promising target for novel control strategies. Using single-cell transcriptomics, we analyzed Plasmodium falciparum development in the mosquito gut, from unfertilized female gametes through the first 20 h after blood feeding, including the zygote and ookinete stages. This study revealed the temporal gene expression of the ApiAP2 family of transcription factors and of parasite stress genes in response to the harsh environment of the mosquito midgut. Further, employing structural protein prediction analyses, we found several upregulated genes predicted to encode intrinsically disordered proteins (IDPs), a category of proteins known for their importance in regulation of transcription, translation, and protein-protein interactions. IDPs are known for their antigenic properties and may serve as suitable targets for antibody- or peptide-based transmission suppression strategies. In total, this study uncovers the P. falciparum transcriptome from early to late parasite development in the mosquito midgut, inside its natural vector, which provides an important resource for future malaria transmission-blocking initiatives.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- malaria
- Plasmodium falciparum
- mosquito midgut
- scRNA-seq
- single cell
- stage transition
- transmission
- molekylär biovetenskap
- Molecular Bioscience
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Mohammed, Mubash ...
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Dziedziech, Alex ...
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Sekar, Vaishnovi
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Ernest, Medard
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Alves E Silva, T ...
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Balan, Balu
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Emami, S. Noushi ...
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Biryukova, Inna
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Friedländer, Mar ...
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Jex, Aaron
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Jacobs-Lorena, M ...
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Henriksson, Joha ...
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Vega-Rodriguez, ...
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Ankarklev, Johan
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Cellbiologi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Bioinformatik oc ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Mikrobiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Microbiology Spe ...
- Av lärosätet
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Stockholms universitet
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Umeå universitet
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Uppsala universitet