Sökning: onr:"swepub:oai:DiVA.org:su-219185" >
The Relevance of Bi...
The Relevance of Biologically Effective Dose for Hearing Preservation After Stereotactic Radiosurgery for Vestibular Schwannomas : A Retrospective Longitudinal Study
-
Tuleasca, Constantin (författare)
-
- Toma-Daşu, Iuliana, 1972- (författare)
- Karolinska Institutet,Stockholms universitet,Fysikum
-
Duroux, Sebastien (författare)
-
visa fler...
-
Starnoni, Daniele (författare)
-
George, Mercy (författare)
-
Maire, Raphael (författare)
-
Daniel, Roy Thomas (författare)
-
Patin, David (författare)
-
Schiappacasse, Luis (författare)
-
- Dasu, Alexandru, 1972- (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,The Skandion Clinic, Uppsala, Sweden,Medicinsk fysik/Skandionkliniken
-
Faouzi, Mohamed (författare)
-
Levivier, Marc (författare)
-
visa färre...
-
(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2023
- 2023
- Engelska.
-
Ingår i: Neurosurgery. - : Ovid Technologies (Wolters Kluwer Health). - 0148-396X .- 1524-4040. ; 92:6, s. 1216-1226
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Stereotactic radiosurgery has become a common treatment approach for small-to-medium size vestibular schwannomas.OBJECTIVE: To evaluate relationship between time (beam-on and treatment) and risk of hearing decline after stereotactic radiosurgery for vestibular schwannomas in patients with Gardner–Robertson (GR) baseline classes I and II.METHODS: This retrospective longitudinal single-center study included 213 patients with GR I and II treated between June 2010 and December 2019. Risk of passing from GR classes I and II (coded 0) to other classes III, IV, and V (coded 1) and the increase in pure tone average (continuous outcome) were evaluated using a mixed-effect regression model. Biologically effective dose (BED) was further assessed for an alpha/beta ratio of 2.47 (Gy2.47).RESULTS: Binary outcome analysis revealed sex, dose rate, integral dose, time [beam-on time odds ratio 1.03, P = .03, 95% CI 1.00-1.06; treatment time (P = .02) and BED (P = .001) as relevant. Fitted multivariable model included the sex, dose rate, and BED. Pure tone average analysis revealed age, integral dose received by tumor, isocenter number, time (beam-on time odds ratio 0.20, P = .001, 95% CI 0.083-0.33) and BED (P = .005) as relevant.CONCLUSION: Our analysis showed that risk of hearing decline was associated with male sex, higher radiation dose rate (cutoff 2.5 Gy/minute), higher integral dose received by the tumor, higher beam-on time ≥20 minutes, and lower BED. A BED between 55 and 61 was considered as optimal for hearing preservation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Biologically effective dose
- Treatment time
- Irradiation time
- Gamma Knife
- Vestibular schwannoma
- Hearing
- Radiosurgery
- Stereotactic radiosurgery
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Tuleasca, Consta ...
-
Toma-Daşu, Iulia ...
-
Duroux, Sebastie ...
-
Starnoni, Daniel ...
-
George, Mercy
-
Maire, Raphael
-
visa fler...
-
Daniel, Roy Thom ...
-
Patin, David
-
Schiappacasse, L ...
-
Dasu, Alexandru, ...
-
Faouzi, Mohamed
-
Levivier, Marc
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Radiologi och bi ...
- Artiklar i publikationen
-
Neurosurgery
- Av lärosätet
-
Stockholms universitet
-
Uppsala universitet
-
Karolinska Institutet