Sökning: onr:"swepub:oai:DiVA.org:su-228132" > Intestinal stroma g...
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001 | oai:DiVA.org:su-228132 | |
003 | SwePub | |
008 | 240410s2024 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:kth-344195 | |
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009 | oai:prod.swepub.kib.ki.se:155279549 | |
009 | oai:DiVA.org:su-232030 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2281322 URI |
024 | 7 | a https://doi.org/10.1038/s41467-024-46076-32 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3441952 URI |
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024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1552795492 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2320302 URI |
040 | a (SwePub)sud (SwePub)kthd (SwePub)kid (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kvedaraite, Egleu Karolinska Institutet4 aut |
245 | 1 0 | a Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF |
264 | 1 | b Springer Nature,c 2024 |
338 | a print2 rdacarrier | |
500 | a QC 20240307 | |
520 | a Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response to inflammation in pediatric IBD and reveal subset-specific inflammatory responses across colon segments and intestinal layers. Using data from a murine dynamic gut injury model and human ex vivo transcriptomic, protein and spatial analyses, we report that PDGFRA+CD142−/low fibroblasts and monocytes/macrophages co-localize in the intestine. In primary human fibroblast-monocyte co-cultures, intestinal PDGFRA+CD142−/low fibroblasts foster monocyte transition to CCR2+CD206+ macrophages through granulocyte-macrophage colony-stimulating factor (GM-CSF). Monocyte-derived CCR2+CD206+ cells from co-cultures have a phenotype similar to intestinal CCR2+CD206+ macrophages from newly diagnosed pediatric IBD patients, with high levels of PD-L1 and low levels of GM-CSF receptor. The study describes subset-specific changes in stromal responses to inflammation and suggests that the intestinal stroma guides intestinal macrophage differentiation. | |
650 | 7 | a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
700 | 1 | a Lourda, Magdau Karolinska Institutet4 aut |
700 | 1 | a Mouratidou, Natalia4 aut |
700 | 1 | a Düking, Tim4 aut |
700 | 1 | a Padhi, Avinashu Karolinska Institutet4 aut |
700 | 1 | a Moll, Kirstenu Karolinska Institutet4 aut |
700 | 1 | a Czarnewski, Paulo,d 1991-u Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)pacz1456 |
700 | 1 | a Sinha, Indranilu Karolinska Institutet4 aut |
700 | 1 | a Xagoraris, Ioannau Karolinska Institutet4 aut |
700 | 1 | a Kokkinou, Efthymia4 aut |
700 | 1 | a Damdimopoulos, Anastasios4 aut |
700 | 1 | a Weigel, Whitney4 aut |
700 | 1 | a Hartwig, Olga4 aut |
700 | 1 | a Santos, Telma E.4 aut |
700 | 1 | a Soini, Teau Karolinska Institutet4 aut |
700 | 1 | a Van Acker, Aline4 aut |
700 | 1 | a Rahkonen, Nelly4 aut |
700 | 1 | a Flodström Tullberg, Malin4 aut |
700 | 1 | a Ringqvist, Emmau Karolinska Institutet4 aut |
700 | 1 | a Buggert, Marcusu Karolinska Institutet4 aut |
700 | 1 | a Jorns, Carlu Karolinska Institutet4 aut |
700 | 1 | a Lindforss, Ulriku Karolinska Institutet4 aut |
700 | 1 | a Nordenvall, Carolineu Karolinska Institutet4 aut |
700 | 1 | a Stamper, Christopher T.u Karolinska Institutet4 aut |
700 | 1 | a Jess, David Unnersjöu KTH,Biofysik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u10c8quf |
700 | 1 | a Akber, Mira4 aut |
700 | 1 | a Nadisauskaite, Ruta4 aut |
700 | 1 | a Jansson, Jessicau Karolinska Institutet4 aut |
700 | 1 | a Vandamme, Niels4 aut |
700 | 1 | a Sorini, Chiarau Karolinska Institutet4 aut |
700 | 1 | a Grundeken, Marijke Elise4 aut |
700 | 1 | a Rolandsdotter, Helenau Karolinska Institutet4 aut |
700 | 1 | a Rassidakis, Georgeu Karolinska Institutet4 aut |
700 | 1 | a Villablanca, Eduardo J.4 aut |
700 | 1 | a Ideström, Maja4 aut |
700 | 1 | a Eulitz, Stefan4 aut |
700 | 1 | a Arnell, Henriku Karolinska Institutet4 aut |
700 | 1 | a Mjösberg, Jenny4 aut |
700 | 1 | a Henter, Jan-Inge4 aut |
700 | 1 | a Svensson, Mattiasu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för biokemi och biofysik4 org |
773 | 0 | t Nature Communicationsd : Springer Natureg 15:1q 15:1x 2041-1723 |
856 | 4 | u https://doi.org/10.1038/s41467-024-46076-3y Fulltext |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-228132 |
856 | 4 8 | u https://doi.org/10.1038/s41467-024-46076-3 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-344195 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:238409190 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:155279549 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-232030 |
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