SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:su-25185"
 

Sökning: onr:"swepub:oai:DiVA.org:su-25185" > Maternal country of...

  • Amoudruz, PetraStockholms universitet,Wenner-Grens institut (författare)

Maternal country of birth and previous pregnancies are associated with breast milk characteristics

  • Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

  • Wiley,2009
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:su-25185
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-25185URI
  • https://doi.org/10.1111/j.1399-3038.2008.00754.xDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-3764URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118161236URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Populations in high infectious exposure countries are at low risk of some immune-mediated diseases such as Crohn’s disease and allergy. This low risk is maintained upon immigration to an industrialized country, but the offspring of such immigrants have a higher immune-mediated disease risk than the indigenous population. We hypothesize that early life exposures in a developing country shape the maternal immune system, which could have implications for the offspring born in a developed country with a low infectious load. The aim of this study was to investigate if exposures in childhood (indicated by country of origin) and subsequent exposures influence immunologic characteristics relevant to stimulation of offspring. Breast milk components among 64 mothers resident in Sweden, 32 of whom immigrated from a developing country, were examined using the ELISA and Cytometric Bead Array methods. Immigrants from a developing country had statistically significantly higher levels of breast milk interleukin-6 (IL-6), IL-8 and transforming growth factor-β1. A larger number of previous pregnancies were associated with down-regulation of several substances, statistically significant for soluble CD14 and IL-8. The results suggest that maternal country of birth may influence adult immune characteristics, potentially relevant to disease risk in offspring. Such a mechanism may explain the higher immune-mediated disease risk among children of migrants from a developing to developed country. Older siblings may influence disease risk through the action of previous pregnancies on maternal immune characteristics.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Holmlund, UlrikaStockholms universitet,Wenner-Grens institut(Swepub:su)ulho0917 (författare)
  • Schollin, JensÖrebro universitet,Hälsoakademin(Swepub:oru)jssn (författare)
  • Sverremark-Ekström, EvaStockholms universitet,Wenner-Grens institut(Swepub:su)esver (författare)
  • Montgomery, Scott MKarolinska Institutet,Örebro universitet,Stockholms universitet,Psykologiska institutionen,Hälsoakademin(Swepub:oru)smy (författare)
  • Stockholms universitetWenner-Grens institut (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Pediatric Allergy and Immunology: Wiley20:1, s. 19-290905-61571399-3038

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy