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Completing the fami...
Completing the family portrait of the anti-apoptotic Bcl-2 proteins: Crystal structure of human Bfl-1 in complex with Bim
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- Herman, Maria Dolores (författare)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Nyman, Tomas (författare)
- Karolinska Institutet
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Welin, Martin (författare)
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- Lehtiö, Lari (författare)
- Karolinska Institutet
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Flodin, Susanne (författare)
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Trésaugues, Lionel (författare)
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Kotenyova, Tetyana (författare)
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Flores, Alex (författare)
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- Nordlund, Pär (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2008-09-21
- 2008
- Engelska.
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Ingår i: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 582:25-26, s. 3590-3594
- Relaterad länk:
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https://febs.onlinel...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Evasion of apoptosis is recognized as a characteristic of malignant growth. Anti-apoptotic B-cell lymphoma-2 (Bcl-2) family members have therefore emerged as potential therapeutic targets due to their critical role in proliferating cancer cells. Here, we present the crystal structure of Bfl-1, the last anti-apoptotic Bcl-2 family member to be structurally characterized, in complex with a peptide corresponding to the BH3 region of the pro-apoptotic protein Bim. The structure reveals distinct features at the peptide-binding site, likely to define the binding specificity for pro-apoptotic proteins. Superposition of the Bfl-1:Bim complex with that of Mcl-1:Bim reveals a significant local plasticity of hydrophobic interactions contributed by the Bim peptide, likely to be the basis for the multi specificity of Bim for anti-apoptotic proteins.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Apoptosis
- B-cell lymphoma-2
- Cancer
- Bfl-1; A1
- Crystal structure
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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