Sökning: onr:"swepub:oai:DiVA.org:su-25618" > Lack of association...
Fältnamn | Indikatorer | Metadata |
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000 | 03355naa a2200505 4500 | |
001 | oai:DiVA.org:su-25618 | |
003 | SwePub | |
008 | 081106s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-256182 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.00042062 DOI |
040 | a (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mangano, Valentina Du Stockholms universitet,Wenner-Grens institut4 aut |
245 | 1 0 | a Lack of association of Interferon Regulatory Factor 1 with severe malaria in affected child‐parental trio studies across three African populations |
264 | c 2009-01-15 | |
264 | 1 | b Public Library of Science (PLoS),c 2009 |
338 | a print2 rdacarrier | |
520 | a Interferon Regulatory Factor 1 (IRF-1) is a member of the IRF family of transcription factors, which have key and diverse roles in the gene-regulatory networks of the immune system. IRF-1 has been described as a critical mediator of IFN-gamma signalling and as the major player in driving TH1 type responses. It is therefore likely to be crucial in both innate and adaptive responses against intracellular pathogens such as Plasmodium falciparum. Polymorphisms at the human IRF1 locus have been previously found to be associated with the ability to control P. falciparum infection in populations naturally exposed to malaria. In order to test whether genetic variation at the IRF1 locus also affects the risk of developing severe malaria, we performed a family-based test of association for 18 Single Nucleotide Polymorphisms (SNPs) across the gene in three African populations, using genotype data from 961 trios consisting of one affected child and his/her two parents (555 from The Gambia, 204 from Kenya and 202 from Malawi). No significant association with severe malaria or severe malaria subphenotypes (cerebral malaria and severe malaria anaemia) was observed for any of the SNPs/haplotypes tested in any of the study populations. Our results offer no evidence that the molecular pathways regulated by the transcription factor IRF-1 are involved in the immune-based pathogenesis of severe malaria. | |
700 | 1 | a Clark, Taane G4 aut |
700 | 1 | a Auburn, Sarah4 aut |
700 | 1 | a Diakite, Mahamadou4 aut |
700 | 1 | a Fry, Andrew E4 aut |
700 | 1 | a Campino, Susana4 aut |
700 | 1 | a Green, Angela4 aut |
700 | 1 | a Richardson, Anna4 aut |
700 | 1 | a Jallow, Muminatou4 aut |
700 | 1 | a Sisay-Joof, Fatou4 aut |
700 | 1 | a Pinder, Margaret4 aut |
700 | 1 | a Griffiths, Michael J4 aut |
700 | 1 | a Peshu, Norbert4 aut |
700 | 1 | a Williams, Thomas N4 aut |
700 | 1 | a Marsh, Kevin4 aut |
700 | 1 | a Molyneux, Malcolm E4 aut |
700 | 1 | a Taylor, Terrie E4 aut |
700 | 1 | a Modiano, David4 aut |
700 | 1 | a Kwiatkowski, Dominic P4 aut |
700 | 1 | a Rockett, Kirk A4 aut |
710 | 2 | a Stockholms universitetb Wenner-Grens institut4 org |
773 | 0 | t PLoS ONEd : Public Library of Science (PLoS)g 4:1, s. e4206-q 4:1<e4206-x 1932-6203 |
856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004206&type=printable |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-25618 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0004206 |
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